The NAD
ART
Antioxidant
Nicotinamide riboside
Postovulatory oocyte aging
Journal
Journal of assisted reproduction and genetics
ISSN: 1573-7330
Titre abrégé: J Assist Reprod Genet
Pays: Netherlands
ID NLM: 9206495
Informations de publication
Date de publication:
26 Oct 2024
26 Oct 2024
Historique:
received:
15
05
2024
accepted:
13
09
2024
medline:
26
10
2024
pubmed:
26
10
2024
entrez:
26
10
2024
Statut:
aheadofprint
Résumé
Postovulatory aging (POA) of oocytes is clinically significant as it mirrors the degeneration observed in maternally aged oocytes, leading to substantial impairments in oocyte quality and the success rates of artificial reproductive technology (ART). The molecular alterations associated with POA, such as the degeneration of the first polar body, an increase in perivitelline space, reactive oxygen species (ROS) accumulation, energy depletion, and chromosomal and DNA damage, underscore the urgency of finding interventions to mitigate these effects. This study aims to identify whether nicotinamide riboside (NR) can prevent POA during the process of in vitro culture and raise the success rates of ART. Taking advantage of an in vitro postovulatory oocyte aging model, we examined the morphological integrity and NAD With 200 μM NR supplementation during in vitro culture for 24 h, the oocytes from POA demonstrated reduced signs of aging-related decline in oocyte quality, including reduced ROS accumulation, improved mitochondrial function, and corrected mis-localization of cortical granules. This improvement in oocyte quality is likely due to the inhibition of oxidative stress via the NAD Current research provides evidence that NR is an efficient and safe natural component that prevents the process of POA and is thus a potential ideal antiaging drug for raising the success rates of ART in clinical practice.
Identifiants
pubmed: 39460833
doi: 10.1007/s10815-024-03263-x
pii: 10.1007/s10815-024-03263-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Fund for Distinguished Young Scholars
ID : 82225019
Organisme : Key Technologies Research and Development Program
ID : 2021YFC2700303
Organisme : Innovative Research Group Project of the National Natural Science Foundation of China
ID : 82192873
Organisme : Innovative Research Group Project of the National Natural Science Foundation of China
ID : 81971381
Organisme : Innovative Research Group Project of the National Natural Science Foundation of China
ID : 82101714
Organisme : Innovative Research Group Project of the National Natural Science Foundation of China
ID : 81771580
Informations de copyright
© 2024. The Author(s).
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