Miro2 sulfhydration by CBS/H

Humans Trophoblasts / metabolism Hydrogen Sulfide / metabolism Cell Movement Female Pregnancy Cystathionine beta-Synthase / metabolism Mitochondrial Dynamics Mitochondria / metabolism rho GTP-Binding Proteins / metabolism Pre-Eclampsia / metabolism Organothiophosphorus Compounds / pharmacology Morpholines / pharmacology Mitochondrial Proteins / metabolism Signal Transduction Adult

Journal

Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092

Informations de publication

Date de publication:
26 Oct 2024
Historique:
received: 27 02 2024
accepted: 17 10 2024
revised: 13 10 2024
medline: 27 10 2024
pubmed: 27 10 2024
entrez: 27 10 2024
Statut: epublish

Résumé

Insufficient cytotrophoblast (CTB) migration and invasion into the maternal myometrium leads to pregnancy related complications like Intra-uterus Growth Restriction (IUGR), and pre-eclampsia (PE). We previously found that hydrogen sulfide (H

Identifiants

DOI: 10.1038/s41419-024-07167-7 PMID: 39461943
pubmed: 39461943
doi: 10.1038/s41419-024-07167-7
pii: 10.1038/s41419-024-07167-7
doi:

Substances chimiques

Hydrogen Sulfide YY9FVM7NSN
Cystathionine beta-Synthase EC 4.2.1.22
rho GTP-Binding Proteins EC 3.6.5.2
GYY 4137 0
Organothiophosphorus Compounds 0
Morpholines 0
Mitochondrial Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

776

Subventions

Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : ZR2020MH023
Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : ZR2021QH096
Organisme : Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation)
ID : ZR2019MH066
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32400994
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82300354
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82271803
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 81873865

Informations de copyright

© 2024. The Author(s).

Références

Brosens I, Robertson WB, Dixon HG. The physiological response of the vessels of the placental bed to normal pregnancy. J Pathol Bacteriol. 1967;93:569–79.
pubmed: 6054057 doi: 10.1002/path.1700930218
Brosens I, Pijnenborg R, Vercruysse L, Romero R. The “Great Obstetrical Syndromes” are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204:193–201.
pubmed: 21094932 doi: 10.1016/j.ajog.2010.08.009
Zhou Y, Damsky CH, Fisher SJ. Preeclampsia is associated with failure of human cytotrophoblasts to mimic a vascular adhesion phenotype. One cause of defective endovascular invasion in this syndrome? J Clin Invest. 1997;99:2152–64.
pubmed: 9151787 pmcid: 508045 doi: 10.1172/JCI119388
Rana S, Lemoine E, Granger JP, Karumanchi SA. Preeclampsia: Pathophysiology, Challenges, and Perspectives. Circ Res. 2019;124:1094–112.
pubmed: 30920918 doi: 10.1161/CIRCRESAHA.118.313276
Wang B, Xu T, Li Y, Wang W, Lyu C, Luo D, et al. Trophoblast H2S Maintains Early Pregnancy via Regulating Maternal-Fetal Interface Immune Hemostasis. J Clin Endocrinol Metab. 2020;105:e4275–89.
pubmed: 32506120 pmcid: 7526739 doi: 10.1210/clinem/dgaa357
Wang K, Ahmad S, Cai M, Rennie J, Fujisawa T, Crispi F, et al. Dysregulation of hydrogen sulfide producing enzyme cystathionine gamma-lyase contributes to maternal hypertension and placental abnormalities in preeclampsia. Circulation. 2013;127:2514–22.
pubmed: 23704251 doi: 10.1161/CIRCULATIONAHA.113.001631
Goldman-Wohl D, Yagel S. Regulation of trophoblast invasion: from normal implantation to pre-eclampsia. Mol Cell Endocrinol. 2002;187:233–8.
pubmed: 11988332 doi: 10.1016/S0303-7207(01)00687-6
Furne J, Springfield J, Koenig T, DeMaster E, Levitt MD. Oxidation of hydrogen sulfide and methanethiol to thiosulfate by rat tissues: a specialized function of the colonic mucosa. Biochem Pharm. 2001;62:255–9.
pubmed: 11389886 doi: 10.1016/S0006-2952(01)00657-8
Braccia DJ, Jiang X, Pop M, Hall AB. The Capacity to Produce Hydrogen Sulfide (H(2)S) via Cysteine Degradation Is Ubiquitous in the Human Gut Microbiome. Front Microbiol. 2021;12:705583.
pubmed: 34745023 pmcid: 8564485 doi: 10.3389/fmicb.2021.705583
Holwerda KM, Bos EM, Rajakumar A, Ris-Stalpers C, van Pampus MG, Timmer A, et al. Hydrogen sulfide producing enzymes in pregnancy and preeclampsia. Placenta. 2012;33:518–21.
pubmed: 22391326 doi: 10.1016/j.placenta.2012.02.014
Fu M, Zhang W, Wu L, Yang G, Li H, Wang R. Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production. Proc Natl Acad Sci USA. 2012;109:2943–8.
pubmed: 22323590 pmcid: 3287003 doi: 10.1073/pnas.1115634109
Chakraborty PK, Murphy B, Mustafi SB, Dey A, Xiong X, Rao G, et al. Cystathionine beta-synthase regulates mitochondrial morphogenesis in ovarian cancer. FASEB J. 2018;32:4145–57.
pubmed: 29494264 pmcid: 6044063 doi: 10.1096/fj.201701095R
Teng H, Wu B, Zhao K, Yang G, Wu L, Wang R. Oxygen-sensitive mitochondrial accumulation of cystathionine beta-synthase mediated by Lon protease. Proc Natl Acad Sci USA. 2013;110:12679–84.
pubmed: 23858469 pmcid: 3732959 doi: 10.1073/pnas.1308487110
Brooks C, Wei Q, Cho SG, Dong Z. Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models. J Clin Invest. 2009;119:1275–85.
pubmed: 19349686 pmcid: 2673870 doi: 10.1172/JCI37829
Bai J, Jiao F, Salmeron AG, Xu S, Xian M, Huang L, et al. Mapping Pregnancy-dependent Sulfhydrome Unfolds Diverse Functions of Protein Sulfhydration in Human Uterine Artery. Endocrinology. 2023;164:1–15.
Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69:1–7.
pubmed: 12620937 doi: 10.1095/biolreprod.102.014977
McNally L, Zhou Y, Robinson JF, Zhao G, Chen LM, Chen H, et al. Up-regulated cytotrophoblast DOCK4 contributes to over-invasion in placenta accreta spectrum. Proc Natl Acad Sci USA. 2020;117:15852–61.
pubmed: 32576693 pmcid: 7355036 doi: 10.1073/pnas.1920776117
Fisher SJ. Why is placentation abnormal in preeclampsia? Am J Obstet Gynecol. 2015;213:S115–22.
pubmed: 26428489 pmcid: 4592742 doi: 10.1016/j.ajog.2015.08.042
Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu. 1972;1:177–91.
pubmed: 4669123
Popova IG, Sitnikova OG, Nazarov SB, Sadov RI, Panova IA, Baev TO, et al. Hydrogen sulfide content in pregnant women with preeclampsia in late gestation and their newborns. Klin Lab Diagn. 2021;66:396–400.
pubmed: 34292680 doi: 10.51620/0869-2084-2021-66-7-396-400
Lu L, Kingdom J, Burton GJ, Cindrova-Davies T. Placental Stem Villus Arterial Remodeling Associated with Reduced Hydrogen Sulfide Synthesis Contributes to Human Fetal Growth Restriction. Am J Pathol. 2017;187:908–20.
pubmed: 28157488 pmcid: 5397715 doi: 10.1016/j.ajpath.2016.12.002
Panagiotopoulos D, Andriopoulou T, Spanou VM, Droggiti DI, Gkavogianni T, Giamarellos-Bourboulis EJ, et al. Deficiency of hydrogen sulfide production and pregnancy rate in an experimental model: Association with preterm delivery. Am J Reprod Immunol. 2023;90:e13764.
pubmed: 37641370 doi: 10.1111/aji.13764
Wang X-L, Tang J, Zhu Y-Q. Focal adhesion kinase signaling is necessary for the hydrogen sulfide-enhanced proliferation, migration, and invasion of HTR8/SVneo human trophoblasts. Reprod Developmental Med. 2023;07:75–82.
Wang X, Yu S, Jian Y, Pan H, Guo J, Wu J, et al. Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells. Front Cardiovasc Med. 2022;9:1023982.
pubmed: 36386317 pmcid: 9647643 doi: 10.3389/fcvm.2022.1023982
Xin L, Junhua W, Long L, Jun Y, Yang X. Exogenous Hydrogen Sulfide Protects SH-SY5Y Cells from OGD/RInduced Injury. Curr Mol Med. 2017;17:563–7.
pubmed: 29473502 doi: 10.2174/1566524018666180222121643
Shen X, Pattillo CB, Pardue S, Bir SC, Wang R, Kevil CG. Measurement of plasma hydrogen sulfide in vivo and in vitro. Free Radic Biol Med. 2011;50:1021–31.
pubmed: 21276849 pmcid: 4798232 doi: 10.1016/j.freeradbiomed.2011.01.025
Wintner EA, Deckwerth TL, Langston W, Bengtsson A, Leviten D, Hill P, et al. A monobromobimane-based assay to measure the pharmacokinetic profile of reactive sulphide species in blood. Br J Pharm. 2010;160:941–57.
doi: 10.1111/j.1476-5381.2010.00704.x
Levitt MD, Abdel-Rehim MS, Furne J. Free and acid-labile hydrogen sulfide concentrations in mouse tissues: anomalously high free hydrogen sulfide in aortic tissue. Antioxid Redox Signal. 2011;15:373–8.
pubmed: 20812866 doi: 10.1089/ars.2010.3525
Seok J, Jun S, Lee JO, Kim GJ. Mitochondrial Dynamics in Placenta-Derived Mesenchymal Stem Cells Regulate the Invasion Activity of Trophoblast. Int J Mol Sci. 2020;21:8599–614.
Seok J, Jun S, Cho J, Park S, Lee JO, Kim GJ. Human placenta-derived mesenchymal stem cells induce trophoblast invasion via dynamic effects on mitochondrial function. J Cell Physiol. 2021;236:6678–90.
pubmed: 33624308 pmcid: 9135125 doi: 10.1002/jcp.30330
Aye I, Aiken CE, Charnock-Jones DS, Smith GCS. Placental energy metabolism in health and disease-significance of development and implications for preeclampsia. Am J Obstet Gynecol. 2022;226:S928–S44.
pubmed: 33189710 doi: 10.1016/j.ajog.2020.11.005
Hebert JF, Myatt L. Placental mitochondrial dysfunction with metabolic diseases: Therapeutic approaches. Biochim Biophys Acta Mol Basis Dis. 2021;1867:165967.
pubmed: 32920120 doi: 10.1016/j.bbadis.2020.165967
Szabo C, Ransy C, Modis K, Andriamihaja M, Murghes B, Coletta C, et al. Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms. Br J Pharm. 2014;171:2099–122.
doi: 10.1111/bph.12369
Nguyen TT, Oh SS, Weaver D, Lewandowska A, Maxfield D, Schuler MH, et al. Loss of Miro1-directed mitochondrial movement results in a novel murine model for neuron disease. Proc Natl Acad Sci USA. 2014;111:E3631–40.
pubmed: 25136135 pmcid: 4156725 doi: 10.1073/pnas.1402449111
Fransson A, Ruusala A, Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J Biol Chem. 2003;278:6495–502.
pubmed: 12482879 doi: 10.1074/jbc.M208609200
Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, et al. Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction. Circ Res. 2019;125:728–43.
pubmed: 31455181 doi: 10.1161/CIRCRESAHA.119.315432
Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, et al. Hydrogen Sulfide-Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016;6:20831.
pubmed: 26877209 pmcid: 4753484 doi: 10.1038/srep20831
Arora P, Mochan S, Gupta SK, Rani N, Kshetrapal P, Dwivedi S, et al. Abnormal trophoblast invasion in early onset preeclampsia: involvement of cystathionine β-synthase, specificity protein 1 and miR-22. bioRxiv. 2023:2023.03.08.531728.
Li T, Chu X, Xin D, Ke H, Wang S, Liu D, et al. H(2)S prevents peripheral immune cell invasion, increasing [Ca(2+)]i and excessive phagocytosis following hypoxia-ischemia injury in neonatal mice. Biomed Pharmacother. 2021;135:111207.
pubmed: 33460958 doi: 10.1016/j.biopha.2020.111207
Ran S, Mu C, Zhu W. Diversity and community pattern of sulfate-reducing bacteria in piglet gut. J Anim Sci Biotechnol. 2019;10:40.
pubmed: 31110701 pmcid: 6513522 doi: 10.1186/s40104-019-0346-5
Ji D, Luo C, Liu J, Cao Y, Wu J, Yan W, et al. Insufficient S-Sulfhydration of Methylenetetrahydrofolate Reductase Contributes to the Progress of Hyperhomocysteinemia. Antioxid Redox Signal. 2022;36:1–14.
pubmed: 34409847 doi: 10.1089/ars.2021.0029
Yang G, Qiu Y. Effects of amlodipine combined with atorvastatin on Th17/Treg imbalance and vascular microcirculation in hypertensive patients with atherosclerosis: A double-blind, single-center randomized controlled trial. Med (Baltim). 2023;102:e32384.
doi: 10.1097/MD.0000000000032384
Zivanovic J, Kouroussis E, Kohl JB, Adhikari B, Bursac B, Schott-Roux S, et al. Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metab. 2019;30:1152–70 e13.
pubmed: 31735592 pmcid: 7185476 doi: 10.1016/j.cmet.2019.10.007
Takata T, Jung M, Matsunaga T, Ida T, Morita M, Motohashi H, et al. Methods in sulfide and persulfide research. Nitric Oxide. 2021;116:47–64.
pubmed: 34534626 pmcid: 8486624 doi: 10.1016/j.niox.2021.09.002

Auteurs

Hao Feng (H)

Department of Obstetrics & Gynecology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.

Zongxin Sun (Z)

Department of Obstetrics & Gynecology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.
Department of Emergency, Affiliated Hospital of Chifeng University, Shifeng, 024001, China.

Baoshi Han (B)

Institute of Women, Children and Reproductive Health, Shandong University, Jinan, 250012, China.

Huitang Xia (H)

Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and Wound Repair, Jinan, Shandong, 250014, PR China.

Lumei Chen (L)

Department of Obstetrics & Gynecology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.

Chunlei Tian (C)

Department of Obstetrics & Gynecology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.

Suhua Yan (S)

Department of Cardiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.

Yugen Shi (Y)

Department of Cardiology, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China.

Jie Yin (J)

Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and Wound Repair, Jinan, Shandong, 250014, PR China.

Wengang Song (W)

Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250012, China.

Peipei Gong (P)

Department of Rehabilitation Medicine, the Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, China.

Shuanglian Wang (S)

Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250012, China. wsl6319@sdu.edu.cn.
ORCID: 0000-0003-4668-8026

Yan Li (Y)

Shandong Provincial Key Laboratory for Rheumatic Disease and Translational Medicine, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250012, China. yli@email.sdfmu.edu.cn.
Translational Medical Research Centre, the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, 250014, China. yli@email.sdfmu.edu.cn.
ORCID: 0000-0002-0366-2048

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Structures de l'embryon › Placenta › Trophoblastes › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Produits chimiques inorganiques › Sulfure d'hydrogène › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Cystathionine beta-synthase › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dynamique mitochondriale › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Pré-éclampsie › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Composés organothiophosphorés › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Oxazines › Morpholines › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Miro2 sulfhydration by CBS/H
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Miro2 sulfhydration by CBS/H