Vitamin C supplementation improves placental function and alters placental gene expression in smokers.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
26 Oct 2024
26 Oct 2024
Historique:
received:
11
01
2024
accepted:
12
09
2024
medline:
27
10
2024
pubmed:
27
10
2024
entrez:
27
10
2024
Statut:
epublish
Résumé
Maternal smoking during pregnancy (MSDP), driven by nicotine crossing the placenta, causes lifelong decreases in offspring pulmonary function and vitamin C supplementation during pregnancy prevents some of those changes. We have also shown in animal models of prenatal nicotine exposure that vitamin C supplementation during pregnancy improves placental function. In this study we examined whether vitamin C supplementation mitigates the effects of MSDP on placental structure, function, and gene expression in pregnant human smokers. Doppler ultrasound was performed in a subset of 55 pregnant smokers participating in the "Vitamin C to Decrease the Effects of Smoking in Pregnancy on Infant Lung Function" (VCSIP) randomized clinical trial (NCT01723696) and in 33 pregnant nonsmokers. Doppler ultrasound measurements showed decreased umbilical vein Doppler velocity (Vmax) in placebo-treated smokers that was significantly improved in smokers randomized to vitamin C, restoring to levels comparable to nonsmokers. RNA-sequencing demonstrated that vitamin C supplementation to pregnant smokers was associated with changes in mRNA expression in genes highly relevant to vascular and cardiac development, suggesting a potential mechanism for vitamin C supplementation in pregnant smokers to improve some aspects of offspring health.
Identifiants
pubmed: 39461975
doi: 10.1038/s41598-024-73005-7
pii: 10.1038/s41598-024-73005-7
doi:
Substances chimiques
Ascorbic Acid
PQ6CK8PD0R
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
25486Subventions
Organisme : NIH HHS
ID : R01 HL105447
Pays : United States
Organisme : NIH HHS
ID : R01 HL 105460
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023288
Pays : United States
Organisme : NIH HHS
ID : P51 OD0110925
Pays : United States
Organisme : NIH HHS
ID : UL1 TR000128
Pays : United States
Informations de copyright
© 2024. The Author(s).
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