Specialized contact sites regulate the fusion of chlamydial inclusion membranes.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 Oct 2024
26 Oct 2024
Historique:
received:
23
02
2024
accepted:
08
10
2024
medline:
27
10
2024
pubmed:
27
10
2024
entrez:
27
10
2024
Statut:
epublish
Résumé
The intracellular bacterial pathogen Chlamydia trachomatis replicates within a membrane-bound compartment called the inclusion. Upon infection with several chlamydiae, each bacterium creates its own inclusion, resulting in multiple inclusions within each host cell. Ultimately, these inclusions fuse together in a process that requires the chlamydial protein IncA. Here, we show that inclusions form unique contact sites (inclusion contact sites, ICSs) prior to fusion, that serve as fusogenic platforms in which specific lipids and chlamydial proteins concentrate. Fusion depends on IncA clustering within ICSs and is regulated by PI(3,4)P
Identifiants
pubmed: 39461996
doi: 10.1038/s41467-024-53443-7
pii: 10.1038/s41467-024-53443-7
doi:
Substances chimiques
Bacterial Proteins
0
IncA protein, Chlamydia trachomatis
0
Sphingolipids
0
Membrane Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9250Subventions
Organisme : NIAID NIH HHS
ID : R01 AI116983
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI181264
Pays : United States
Informations de copyright
© 2024. The Author(s).
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