Does gut microbiota dysbiosis impact the metabolic alterations of hydrogen sulfide and lanthionine in patients with chronic kidney disease?
Humans
Gastrointestinal Microbiome
Hydrogen Sulfide
/ metabolism
Renal Insufficiency, Chronic
/ microbiology
Male
Female
Middle Aged
Dysbiosis
/ microbiology
Feces
/ microbiology
Aged
Sulfides
/ metabolism
Adult
Renal Dialysis
Bacteria
/ classification
Alanine
/ analogs & derivatives
Case-Control Studies
Chronic kidney disease
Dysbiosis
Gut microbiota
Hemodialysis
Hydrogen sulfide (H2S)
Kidney transplant
Lanthionine
Journal
BMC microbiology
ISSN: 1471-2180
Titre abrégé: BMC Microbiol
Pays: England
ID NLM: 100966981
Informations de publication
Date de publication:
26 Oct 2024
26 Oct 2024
Historique:
received:
24
02
2024
accepted:
18
10
2024
medline:
27
10
2024
pubmed:
27
10
2024
entrez:
27
10
2024
Statut:
epublish
Résumé
Chronic Kidney Disease (CKD) is characterized by a methionine-related metabolic disorder involving reduced plasma levels of hydrogen sulfide (H The gut microbiota of 88 CKD patients (non-dialysis, hemodialysis, and transplant patients) and 26 healthy controls were profiled using 16 S-amplicon sequencing. H The CKD population exhibited a tenfold increase in serum lanthionine associated with kidney dysfunction. Despite lanthionine retention, hemodialysis and transplant patients had significantly lower serum H The metabolic deregulation of H
Sections du résumé
BACKGROUND
BACKGROUND
Chronic Kidney Disease (CKD) is characterized by a methionine-related metabolic disorder involving reduced plasma levels of hydrogen sulfide (H
METHODS
METHODS
The gut microbiota of 88 CKD patients (non-dialysis, hemodialysis, and transplant patients) and 26 healthy controls were profiled using 16 S-amplicon sequencing. H
RESULTS
RESULTS
The CKD population exhibited a tenfold increase in serum lanthionine associated with kidney dysfunction. Despite lanthionine retention, hemodialysis and transplant patients had significantly lower serum H
CONCLUSIONS
CONCLUSIONS
The metabolic deregulation of H
Identifiants
pubmed: 39462312
doi: 10.1186/s12866-024-03590-0
pii: 10.1186/s12866-024-03590-0
doi:
Substances chimiques
Hydrogen Sulfide
YY9FVM7NSN
lanthionine
JO78O46X3K
Sulfides
0
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
436Subventions
Organisme : European Union's Horizon 2020 research and innovation program
ID : Grant agreement No [860329]
Organisme : European Union's Horizon 2020 research and innovation program
ID : Grant agreement No [860329]
Organisme : European Union's Horizon 2020 research and innovation program
ID : Grant agreement No [860329]
Informations de copyright
© 2024. The Author(s).
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