N-glycosylation of the envelope glycoprotein I is essential for the proliferation and virulence of the duck plague virus.
Duck plague virus
N-glycosylation
glycoprotein I
pathogenicity
virulence gene
Journal
Veterinary research
ISSN: 1297-9716
Titre abrégé: Vet Res
Pays: England
ID NLM: 9309551
Informations de publication
Date de publication:
26 Oct 2024
26 Oct 2024
Historique:
received:
24
04
2024
accepted:
26
08
2024
medline:
27
10
2024
pubmed:
27
10
2024
entrez:
27
10
2024
Statut:
epublish
Résumé
Duck plague virus (DPV) causes the highly pathogenic duck plague, and the envelope glycoprotein I (gI), as one of the key virulence genes, has not yet had its critical virulence sites identified through screening. This study used reverse genetics technology to target the gI, specifically within the DPV genome. Four DPV mutants with gI N-glycosylation site mutations were designed and constructed, and these mutant strains were successfully rescued. Our results confirmed that three asparagine residues of gI (N
Identifiants
pubmed: 39462432
doi: 10.1186/s13567-024-01398-4
pii: 10.1186/s13567-024-01398-4
doi:
Substances chimiques
Viral Envelope Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
139Subventions
Organisme : National Natural Science Foundation of China
ID : 32072894
Organisme : China Agriculture Research System of MOF and MARA
ID : CARS-42-17
Organisme : Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System
ID : SCCXTD-2020-18
Informations de copyright
© 2024. The Author(s).
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