Development of a novel immunocompetent murine tumor model for urothelial carcinoma using in vivo electroporation.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 10 2024
27 10 2024
Historique:
received:
31
01
2024
accepted:
21
10
2024
medline:
28
10
2024
pubmed:
28
10
2024
entrez:
28
10
2024
Statut:
epublish
Résumé
A lack of advanced preclinical mouse tumor models impedes the progress in urothelial carcinoma research. We present here a novel fast, robust, reliable, and highly reproducible model for the genetic induction of bladder cancer in immunocompetent mice. Different sets of oncogenic transposons (Cmyc, Kras) and Cre drivers were transfected into the murine bladder wall of two different genetic backgrounds (Trp53
Identifiants
pubmed: 39463382
doi: 10.1038/s41598-024-77178-z
pii: 10.1038/s41598-024-77178-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25619Informations de copyright
© 2024. The Author(s).
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