Sodium bicarbonate use in the treatment of idiopathic intracranial hypertension.


Journal

Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986

Informations de publication

Date de publication:
27 Oct 2024
Historique:
received: 20 01 2024
accepted: 21 10 2024
revised: 15 10 2024
medline: 28 10 2024
pubmed: 28 10 2024
entrez: 28 10 2024
Statut: aheadofprint

Résumé

This retrospective case-control study from 2008 to 2022 aimed to determine the effect of adjunctive sodium bicarbonate (NaHCO Retrospective data was collected via chart review. 288 eyes of 144 patients with IIH, including those taking ACZ alone (control group, n = 89) vs. ACZ and NaHCO Cox proportional hazards model for the primary outcome yielded a hazard ratio of 0.800, which was statistically insignificant (95% CI, 0.57-1.13; p = 0.200). There was no significant difference between groups when comparing RNFL, VFMD, VA, surgical intervention, or discontinuation of ACZ. The treatment group was more likely to experience side effects from ACZ prior to starting sodium bicarbonate therapy (p < 0.001). Among the treatment group, 92.7% remained on NaHCO Sodium bicarbonate does not appear to impact treatment outcomes in patients taking acetazolamide for IIH. Sodium bicarbonate may represent a reasonable adjunctive medication to help mitigate acetazolamide-related side effects in this group of patients.

Identifiants

pubmed: 39463413
doi: 10.1038/s41433-024-03436-z
pii: 10.1038/s41433-024-03436-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)
ID : 8 UL1 TR000114-02

Informations de copyright

© 2024. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.

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Auteurs

Mikayla J Baker (MJ)

Department of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Ziou Jiang (Z)

Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.

Collin McClelland (C)

Department of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA.

Michael S Lee (MS)

Department of Ophthalmology & Visual Neurosciences, University of Minnesota, Minneapolis, MN, USA. mikelee@umn.edu.

Classifications MeSH