The effect of blood lipids on the comorbidity of multiple large arachnoid granulations.
Arachnoid granulation
Blood lipid
Cerebral venous sinus stenosis
Dyslipidemia
High-resolution black blood magnetic resonance imaging
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
28 Oct 2024
28 Oct 2024
Historique:
received:
10
08
2024
accepted:
22
10
2024
medline:
28
10
2024
pubmed:
28
10
2024
entrez:
28
10
2024
Statut:
epublish
Résumé
Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research. The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs. A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs. TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.
Sections du résumé
BACKGROUND
BACKGROUND
Currently, studies on the formation mechanism for the enlargement of arachnoid granulation (AG) are lacking. The impact of dyslipidemia on the formation of multiple large arachnoid granulations (LAGs) was studied in this research.
METHODS
METHODS
The study included patients diagnosed with cerebral venous sinus stenosis (CVSS) related to LAG. The number of LAGs was assessed via high-resolution black blood magnetic resonance imaging. The relationships between blood lipids and multiple LAGs were explored to evaluate the effects of dyslipidemia on the formation of multiple LAGs.
RESULTS
RESULTS
A total of 163 participants with a diagnosis of LAG were included. The levels of total cholesterol (TC) (P = 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.01) in the multiple LAGs group were greater than those in the non-multiple LAGs group. Multivariate logistic regression analysis revealed that TC (odds ratio (OR), 2.19; 95% confidence interval (CI), 1.26-3.80; P = 0.006) and LDL-c (OR, 2.18; 95% CI, 1.16-4.07; P = 0.02) were independently associated with multiple LAGs.
CONCLUSIONS
CONCLUSIONS
TC and LDL-c are independently related to multiple LAGs, indicating that dyslipidemia may be a potential cause of CVSS. Therefore, monitoring blood lipids may be necessary for patients with LAGs.
Identifiants
pubmed: 39465359
doi: 10.1186/s12944-024-02341-4
pii: 10.1186/s12944-024-02341-4
doi:
Substances chimiques
Cholesterol, LDL
0
Cholesterol
97C5T2UQ7J
Lipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
351Subventions
Organisme : National Natural Science Foundation of China
ID : 82171297, 82101390
Organisme : Natural Science Foundation of Beijing Municipality
ID : 7212047
Informations de copyright
© 2024. The Author(s).
Références
Arjona A, Delgado F, Fernandez-Romero E. Intracranial hypertension secondary to giant arachnoid granulations. J Neurol Neurosurg Psychiatry. 2003;74:418.
doi: 10.1136/jnnp.74.4.418
pubmed: 12640052
pmcid: 1738403
Watane GV, Patel B, Brown D, Taheri MR. The significance of Arachnoid Granulation in patients with idiopathic intracranial hypertension. J Comput Assist Tomogr. 2018;42:282–5.
doi: 10.1097/RCT.0000000000000668
pubmed: 28937488
Khanna D, Peltzer C, Kahar P, Parmar MS. Body Mass Index (BMI): a Screening Tool Analysis. Cureus. 2022;14:e22119.
pubmed: 35308730
pmcid: 8920809
Beatty RM, Hornig GW, Hanson EJ. Jr. Protruding arachnoid granulations mimicking dermoid cysts. J Pediatr Surg. 1989;24:411–3.
doi: 10.1016/S0022-3468(89)80285-4
pubmed: 2732889
Ference BA, Graham I, Tokgozoglu L, Catapano AL. Reprint of: impact of lipids on Cardiovascular Health: JACC Health Promotion Series. J Am Coll Cardiol. 2018;72:2980–95.
doi: 10.1016/j.jacc.2018.10.021
pubmed: 30522632
Goldstein JL, Brown MS. A century of cholesterol and coronaries: from plaques to genes to statins. Cell. 2015;161:161–72.
doi: 10.1016/j.cell.2015.01.036
pubmed: 25815993
pmcid: 4525717
Bir SC, Kelley RE. Carotid atherosclerotic disease: a systematic review of pathogenesis and management. Brain Circ. 2022;8:127–36.
doi: 10.4103/bc.bc_36_22
pubmed: 36267431
pmcid: 9578307
Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006;295:1556–65.
doi: 10.1001/jama.295.13.jpc60002
pubmed: 16533939
Nicholls SJ, Ballantyne CM, Barter PJ, Chapman MJ, Erbel RM, Libby P, et al. Effect of two intensive statin regimens on progression of coronary disease. N Engl J Med. 2011;365:2078–87.
doi: 10.1056/NEJMoa1110874
pubmed: 22085316
Yahagi K, Kolodgie FD, Otsuka F, Finn AV, Davis HR, Joner M, et al. Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis. Nat Rev Cardiol. 2016;13:79–98.
doi: 10.1038/nrcardio.2015.164
pubmed: 26503410
Kockx MM, Cambier BA, Bortier HE, De Meyer GR, Declercq SC, van Cauwelaert PA, et al. Foam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts. Histopathology. 1994;25:365–71.
doi: 10.1111/j.1365-2559.1994.tb01355.x
pubmed: 7835842
Domanski MJ, Borkowf CB, Campeau L, Knatterud GL, White C, Hoogwerf B, et al. Prognostic factors for atherosclerosis progression in saphenous vein grafts: the postcoronary artery bypass graft (Post-CABG) trial. Post-CABG trial investigators. J Am Coll Cardiol. 2000;36:1877–83.
doi: 10.1016/S0735-1097(00)00973-6
pubmed: 11092659
Knatterud GL, Rosenberg Y, Campeau L, Geller NL, Hunninghake DB, Forman SA, et al. Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators Circulation. 2000;102:157–65.
pubmed: 10889125
Tanaka H, Zaima N, Sasaki T, Yamamoto N, Sano M, Konno H, et al. Loss of lymphatic vessels and regional lipid accumulation is associated with great saphenous vein incompetence. J Vasc Surg. 2012;55:1440–8.
doi: 10.1016/j.jvs.2011.09.064
pubmed: 22226181
Stolz E, Valdueza JM, Grebe M, Schlachetzki F, Schmitt E, Madlener K, et al. Anemia as a risk factor for cerebral venous thrombosis? An old hypothesis revisited. Results of a prospective study. J Neurol. 2007;254:729–34.
doi: 10.1007/s00415-006-0411-9
pubmed: 17450317
Qiu X, Zhao P, Li X, Ding H, Lv H, Zeng R, et al. The relationships among transverse sinus stenosis measured by CT venography, venous trans-stenotic pressure gradient and intracranial pressure in patients with unilateral venous pulsatile Tinnitus. Front Neurosci. 2021;15:694731.
doi: 10.3389/fnins.2021.694731
pubmed: 34539330
pmcid: 8446348
Leach JL, Meyer K, Jones BV, Tomsick TA. Large arachnoid granulations involving the dorsal superior sagittal sinus: findings on MR imaging and MR Venography. AJNR Am J Neuroradiol. 2008;29:1335–9.
doi: 10.3174/ajnr.A1093
pubmed: 18417601
pmcid: 8119153
Mehta RI, Mehta RI. Giant Arachnoid granulations: a systematic literature review. Int J Mol Sci. 2023; 24.
Sun Y, Hou XH, Wang DD, Ma YH, Tan CC, Sun FR, et al. Apolipoprotein B/AI ratio as an independent risk factor for intracranial atherosclerotic stenosis. Aging. 2019;11:6851–62.
doi: 10.18632/aging.102216
pubmed: 31479420
pmcid: 6756877
Enomoto M, Adachi H, Hirai Y, Fukami A, Satoh A, Otsuka M et al. LDL-C/HDL-C Ratio Predicts Carotid Intima-Media Thickness Progression Better Than HDL-C or LDL-C Alone. J Lipids. 2011; 2011:549137.
Yang WS, Li R, Shen YQ, Wang XC, Liu QJ, Wang HY, et al. Importance of lipid ratios for predicting intracranial atherosclerotic stenosis. Lipids Health Dis. 2020;19:160.
doi: 10.1186/s12944-020-01336-1
pubmed: 32622367
pmcid: 7335436
Yang Q, Duan J, Fan Z, Qu X, Xie Y, Nguyen C, et al. Early detection and quantification of cerebral venous thrombosis by magnetic resonance black-blood Thrombus imaging. Stroke. 2016;47:404–9.
doi: 10.1161/STROKEAHA.115.011369
pubmed: 26670082
Wang G, Yang X, Duan J, Zhang N, Maya MM, Xie Y, et al. Cerebral venous thrombosis: MR Black-blood Thrombus imaging with enhanced blood Signal suppression. AJNR Am J Neuroradiol. 2019;40:1725–30.
pubmed: 31558501
pmcid: 6785400
Yang X, Wu F, Liu Y, Duan J, Fisher M, Ji X, et al. Diagnostic performance of MR black-blood thrombus imaging for cerebral venous thrombosis in real-world clinical practice. Eur Radiol. 2022;32:2041–9.
doi: 10.1007/s00330-021-08286-x
pubmed: 34542696
Mollan SP, Ali F, Hassan-Smith G, Botfield H, Friedman DI, Sinclair AJ. Evolving evidence in adult idiopathic intracranial hypertension: pathophysiology and management. J Neurol Neurosurg Psychiatry. 2016;87:982–92.
doi: 10.1136/jnnp-2015-311302
pubmed: 26888960
Lee JM, Gebremariam A, Card-Higginson P, Shaw JL, Thompson JW, Davis MM. Poor performance of body mass index as a marker for hypercholesterolemia in children and adolescents. Arch Pediatr Adolesc Med. 2009;163:716–23.
doi: 10.1001/archpediatrics.2009.109
pubmed: 19652103
Nowak-Göttl U, Junker R, Hartmeier M, Koch HG, Münchow N, Assmann G, et al. Increased lipoprotein(a) is an important risk factor for venous thromboembolism in childhood. Circulation. 1999;100:743–8.
doi: 10.1161/01.CIR.100.7.743
pubmed: 10449697
Skuza AA, Polak M, Undas A. Elevated lipoprotein(a) as a new risk factor of cerebral venous sinus thrombosis: association with fibrin clot properties. J Thromb Thrombolysis. 2019;47:8–15.
doi: 10.1007/s11239-018-1769-0
pubmed: 30511257
Yazdani SK, Farb A, Nakano M, Vorpahl M, Ladich E, Finn AV, et al. Pathology of drug-eluting versus bare-metal stents in saphenous vein bypass graft lesions. JACC Cardiovasc Interv. 2012;5:666–74.
doi: 10.1016/j.jcin.2011.12.017
pubmed: 22721663
pmcid: 3407956
The effect of. Aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. N Engl J Med. 1997;336:153–62.
doi: 10.1056/NEJM199701163360301
Yang L, Li T, Zha L. Foxc2 alleviates Ox-LDL-Induced lipid Accumulation, inflammation, and apoptosis of macrophage via regulating the expression of Angptl2. Inflammation. 2020;43:1397–410.
doi: 10.1007/s10753-020-01217-w
pubmed: 32170602
Bian W, Jing X, Yang Z, Shi Z, Chen R, Xu A, et al. Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis. Aging. 2020;12:6385–400.
doi: 10.18632/aging.103034
pubmed: 32267831
pmcid: 7185106
Mehta RI, Mangla R, Mehta RI. Giant Arachnoid granulations: diagnostic workup and characterization in three symptomatic adults. Int J Mol Sci. 2023; 24.