Macrophage membrane-functionalized manganese dioxide nanomedicine for synergistic treatment of atherosclerosis by mitigating inflammatory storms and promoting cholesterol efflux.


Journal

Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208

Informations de publication

Date de publication:
28 Oct 2024
Historique:
received: 11 07 2024
accepted: 19 10 2024
medline: 28 10 2024
pubmed: 28 10 2024
entrez: 28 10 2024
Statut: epublish

Résumé

Atherosclerosis (AS) poses a significant threat to human life and health. However, conventional antiatherogenic medications exhibit insufficient targeting precision and restricted therapeutic effectiveness. Moreover, during the progression of AS, macrophages undergo polarization toward the proinflammatory M1 phenotype and generate reactive oxygen species (ROS) to accelerate the occurrence of inflammatory storms, and ingest excess lipids to form foam cells by inhibiting cholesterol efflux. In our study, we developed a macrophage membrane-functionalized hollow mesoporous manganese dioxide nanomedicine (Col@HMnO

Identifiants

pubmed: 39465387
doi: 10.1186/s12951-024-02939-x
pii: 10.1186/s12951-024-02939-x
doi:

Substances chimiques

Oxides 0
Manganese Compounds 0
Cholesterol 97C5T2UQ7J
manganese dioxide TF219GU161
Reactive Oxygen Species 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

664

Subventions

Organisme : Chongqing Municipal Education Commission
ID : CYB23199
Organisme : National Natural Science Foundation of China
ID : No. 82302164
Organisme : National Natural Science Foundation of China
ID : No. 82102063
Organisme : National Natural Science Foundation of China
ID : No. 82271970
Organisme : Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission
ID : cstc2021jcyj -msxmX0040

Informations de copyright

© 2024. The Author(s).

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Auteurs

Sijin Chen (S)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Wenli Zhang (W)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Chun Tang (C)

Department of Spine Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Xiyue Rong (X)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Yun Liu (Y)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Ying Luo (Y)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Lian Xu (L)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Zhongsheng Xu (Z)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Junrui Wang (J)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Yi Wang (Y)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Qianying Du (Q)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Bo Liu (B)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chongqing Key Laboratory of Ultrasound Molecular Imaging, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Yu Zhang (Y)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.

Jia Liu (J)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 302956@hospital.cqmu.edu.cn.

Dajing Guo (D)

Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. guodaj@163.com.

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