Body mass index trajectories from birth to early adulthood and lung function development.
Journal
The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460
Informations de publication
Date de publication:
28 Oct 2024
28 Oct 2024
Historique:
received:
12
02
2024
accepted:
14
09
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
28
10
2024
Statut:
aheadofprint
Résumé
Limited studies have investigated the influence of body mass index (BMI) trajectories on lung function covering the entire growth period. We conducted a prospective study utilizing data from the Swedish BAMSE birth cohort. Latent class mixture modelling was employed to examine the diversity in BMI z-scores from birth to 24 years of age. Participants with four or more BMI z-scores were included (n=3204, 78·4%). Pre-bronchodilator (BD) spirometry was tested at 8, 16, and 24 years, while post-BD spirometry, multiple-breath nitrogen washout (for lung clearance index, LCI), and urinary metabolomics data were assessed at 24 years. Six distinct BMI development groups were identified. Compared to the stable normal BMI group, the accelerated increasing BMI group exhibited reduced pre- and post-BD FEV Early interventions aiming for normal BMI during childhood may contribute to improved lung health later in life.
Sections du résumé
BACKGROUND
BACKGROUND
Limited studies have investigated the influence of body mass index (BMI) trajectories on lung function covering the entire growth period.
METHODS
METHODS
We conducted a prospective study utilizing data from the Swedish BAMSE birth cohort. Latent class mixture modelling was employed to examine the diversity in BMI z-scores from birth to 24 years of age. Participants with four or more BMI z-scores were included (n=3204, 78·4%). Pre-bronchodilator (BD) spirometry was tested at 8, 16, and 24 years, while post-BD spirometry, multiple-breath nitrogen washout (for lung clearance index, LCI), and urinary metabolomics data were assessed at 24 years.
RESULTS
RESULTS
Six distinct BMI development groups were identified. Compared to the stable normal BMI group, the accelerated increasing BMI group exhibited reduced pre- and post-BD FEV
CONCLUSIONS
CONCLUSIONS
Early interventions aiming for normal BMI during childhood may contribute to improved lung health later in life.
Identifiants
pubmed: 39467611
pii: 13993003.00298-2024
doi: 10.1183/13993003.00298-2024
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
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