Formaldehyde initiates memory and motor impairments under weightlessness condition.


Journal

NPJ microgravity
ISSN: 2373-8065
Titre abrégé: NPJ Microgravity
Pays: United States
ID NLM: 101703605

Informations de publication

Date de publication:
28 Oct 2024
Historique:
received: 27 10 2023
accepted: 21 10 2024
medline: 29 10 2024
pubmed: 29 10 2024
entrez: 29 10 2024
Statut: epublish

Résumé

During space flight, prolonged weightlessness stress exerts a range of detrimental impacts on the physiology and psychology of astronauts. These manifestations encompass depressive symptoms, anxiety, and impairments in both short-term memory and motor functions, albeit the precise underlying mechanisms remain elusive. Recent studies have revealed that hindlimb unloading (HU) animal models, which simulate space weightlessness, exhibited a disorder in memory and motor function associated with endogenous formaldehyde (FA) accumulation in the hippocampus and cerebellum, disruption of brain extracellular space (ECS), and blockage of interstitial fluid (ISF) drainage. Notably, the impairment of the blood-brain barrier (BBB) caused by space weightlessness elicits the infiltration of albumin and hemoglobin from the blood vessels into the brain ECS. However, excessive FA has the potential to form cross-links between these two proteins and amyloid-beta (Aβ), thereby obstructing ECS and inducing neuron death. Moreover, FA can inhibit N-methyl-D-aspartate (NMDA) currents by crosslinking NR1 and NR2B subunits, thus impairing memory. Additionally, FA has the ability to modulate the levels of certain microRNAs (miRNAs) such as miRNA-29b, which can affect the expression of aquaporin-4 (AQP4) so as to regulate ECS structure and ISF drainage. Especially, the accumulation of FA may inactivate the ataxia telangiectasia-mutated (ATM) protein kinase by forming cross-linking, a process that is associated with ataxia. Hence, this review presents that weightlessness stress-derived FA may potentially serve as a crucial catalyst in the deterioration of memory and motor abilities in the context of microgravity.

Identifiants

pubmed: 39468074
doi: 10.1038/s41526-024-00441-0
pii: 10.1038/s41526-024-00441-0
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

100

Subventions

Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82071214
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 82071214

Informations de copyright

© 2024. The Author(s).

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Auteurs

Tianhao Mei (T)

Beijing Geriatric Hospital, Beijing, China.
Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Ying Chen (Y)

Beijing Geriatric Hospital, Beijing, China.
Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Yajuan Gao (Y)

Department of Radiology, Peking University Third Hospital, Beijing, China. Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, China.
NMPA key Laboratory for Evaluation of Medical Imaging Equipment and Technique, Beijing, China.
Institute of Medical Technology, Peking University Health Science Center, Beijing, China.

Hang Zhao (H)

Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Xingzhou Lyu (X)

Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Jing Lin (J)

Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Tianye Niu (T)

Shenzhen Bay Laboratory, Shenzhen, China. niuty@szbl.ac.cn.
University of Science and Technology of China, Anhui, China. niuty@szbl.ac.cn.

Hongbin Han (H)

Department of Radiology, Peking University Third Hospital, Beijing, China. Key Laboratory of Magnetic Resonance Imaging Equipment and Technique, Beijing, China. hanhongbin@bjmu.edu.cn.
NMPA key Laboratory for Evaluation of Medical Imaging Equipment and Technique, Beijing, China. hanhongbin@bjmu.edu.cn.
Institute of Medical Technology, Peking University Health Science Center, Beijing, China. hanhongbin@bjmu.edu.cn.

Zhiqian Tong (Z)

Beijing Geriatric Hospital, Beijing, China. tzqbeida@ccmu.edu.cn.
Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China. tzqbeida@ccmu.edu.cn.

Classifications MeSH