Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries.
HIV infection
IL-6
Inflammatory biomarkers
PAMPs and DAMPs
Pediatric population
Predictive model
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 10 2024
28 10 2024
Historique:
received:
21
05
2024
accepted:
23
09
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
In this work our aim was to identify early biomarkers in plasma samples associated with mortality in children with perinatal HIV treated early in life, to potentially inform early intervention targeting this vulnerable group. 20/215 children (9.3%) with perinatal HIV, enrolled within 3 months of age died prematurely within the first year of the study, despite early ART initiation. Using a propensity score, we selected 40 alive study participants having similar clinical and virological records compared to the deceased group. 13 HIV unexposed (HU) healthy children were additionally used as controls. Baseline plasma samples were analyzed using a targeted proteomic approach, and to assess pathogen-associated and damage-associated molecular patterns (PAMPs, DAMPs) levels. Data from deceased participants were compared to both control groups, with multivariate logistic regression models used to evaluate the association between mortality and plasma proteins. We developed a machine learning model to predict mortality risk, finding that IL-6 and CXCL11 not only were higher in deceased children than Matched-children with HIV (p < 0.001 and p = 0.0034) but also predictive of mortality (accuracy of 77%); levels of PAMPs were higher in deceased children (p = 0.0016). Thus, measuring early inflammatory biomarkers, particularly IL-6, could help mortality risk prediction and potentially guide targeted interventions.
Identifiants
pubmed: 39468166
doi: 10.1038/s41598-024-74066-4
pii: 10.1038/s41598-024-74066-4
doi:
Substances chimiques
Biomarkers
0
Interleukin-6
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25792Investigateurs
Paolo Rossi
(P)
Silvia Faggion
(S)
Daniel Gomez Pena
(DG)
Inger Lindfors Rossi
(IL)
Federica D'Ambrosio
(F)
Andrea Oletto
(A)
Francesca Mazzetto
(F)
Musakanya Ching'andu
(M)
Alessandra Nardone
(A)
William James
(W)
Nicola Cotugno
(N)
Paola Zangari
(P)
Carla Paganin
(C)
Paolo Palma
(P)
Alfredo Tagarro
(A)
Anita De Rossi
(A)
Sara Dominguez-Rodriguez
(S)
Louise Kuhn
(L)
Andrew Yates
(A)
Mark F Cotton
(MF)
Shaun Barnabas
(S)
Avy Violari
(A)
Kennedy Otwombe
(K)
Paula Vaz
(P)
Maria Grazia Lain
(MG)
Moira Spyer
(M)
Eleni Nastouli
(E)
Kathleen Gartner
(K)
Elisa López
(E)
Sheila Fernandez-Luis
(S)
Denise Naniche
(D)
Tacilta Nhampossa
(T)
Almoustapha Maiga
(A)
Mariam Sylla
(M)
Pablo Rojo
(P)
Carlo Giaquinto
(C)
Mathias Lichterfeld
(M)
Nigel Klein
(N)
Carlota Miranda
(C)
Savita Pahwa
(S)
Anne-Genevieve Marcelin
(AG)
Vincent Calvez
(V)
Caroline Foster
(C)
Deborah Persaud
(D)
Viviana Giannuzzi
(V)
Annalisa Landi
(A)
Adriana Ceci
(A)
Ofer Levy
(O)
Philip Goulder
(P)
Holly Peay
(H)
Thanyawee Puthanakit
(T)
Cissy Kityo
(C)
Informations de copyright
© 2024. The Author(s).
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