Frequency selective metasurface based radio frequency glucose sensor with a periodic array of meta cells.

Product innovation Frequency selective surface Health-care electronics Maxwell-Garnett approximation Metasurface Non-invasive glucose measurement

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
28 10 2024
Historique:
received: 26 07 2024
accepted: 16 10 2024
medline: 29 10 2024
pubmed: 29 10 2024
entrez: 29 10 2024
Statut: epublish

Résumé

Nowadays, the operating principle of most of the experimental electromagnetic glucose sensors is based on the effect of an anomalous dispersion caused by a direct contact between an object under test and a two-dimensional metasurface. Due to the repeated uses, the metasurface will be subjected to a chemical attack over time. To avoid this problem, this work proposes a novel glucose sensor that is equipped with an interfacial dielectric layer of 0.254 mm thickness to separate the object under test and the metasurface. The results of our analysis suggest that, if the interfacial dielectric layer is sufficiently thin, there will be no shortage of sensitivity in the proposed sensor. Consistent with our theoretical prediction, the proposed sensor was found to resonate at 9-10 GHz, with its resonant frequency responding to the glucose concentration in a dose dependent manner. The correlation the resonant frequency shift and the glucose concentration was found to be highly linear over the clinical diabetic range with a sensitivity of 4 MHz/(mg dL

Identifiants

pubmed: 39468173
doi: 10.1038/s41598-024-76741-y
pii: 10.1038/s41598-024-76741-y
doi:

Substances chimiques

Glucose IY9XDZ35W2
Blood Glucose 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

25716

Subventions

Organisme : Researchers Supporting Project, King Saud University, Riyadh, Saudi Arabia
ID : RSP2024R482

Informations de copyright

© 2024. The Author(s).

Références

Elsheakh, D. M. et al. Rapid detection of coronavirus (COVID-19) using microwave immunosensor cavity resonator. Sensors 21, 7021 (2021).
doi: 10.3390/s21217021 pubmed: 34770328 pmcid: 8588152
Ali, R. A. S. et al. Instantaneous viral detection of SARS-CoV‐2 and beyond using electromagnetic sensing. Adv. Sens. Res. 3(4) (2023).
Wang, P. J. et al. Microwave resonant absorption of SARS-CoV-2 viruses. Sci. Rep. 12, 12596 (2022).
doi: 10.1038/s41598-022-16845-5 pubmed: 35869163 pmcid: 9307221
Garcia, H. C. et al. Detection of glucose variability in saline solutions from transmission and reflection measurements using V-band waveguides. Meas. Sci. Technol. 26 (12), 125701 (2015).
doi: 10.1088/0957-0233/26/12/125701
Baird, C. Lecture 2 Notes, Electromagnetic Theory II (University of Massachusetts, 2024).
Jayanthi, R. K. R., Virdee, B. S., Lubangakene, I., Ganguly, P. & Mariyanayagam, D. The effect of temperature on permittivity measurements of aqueous solutions of glucose for the development of non-invasive glucose sensors based on electromagnetic waves. Results Eng. 20, 101506 (2023).
Kim, N. Y., Dhakal, R., Adhikari, K. K., Kim, E. S. & Wang, C. A reusable robust radio frequency biosensor using microwave resonator by integrated passive device technology for quantitative detection of glucose level. Biosens. Bioelectron. 67, 687693 (2015).
doi: 10.1016/j.bios.2014.10.021
Heungjae et al. October design and in vitro interference test of microwave noninvasive blood glucose monitoring sensor. IEEE Trans. Microwave Theory Tech. 63, 10 (2015).
Kandwal, A. et al. A novel method of using bifilar spiral resonator for designing thin robust flexible glucose sensors. IEEE Trans. Instrum. Meas. 70, 1–10 (2021).
Kandwal, A. et al. Highly sensitive closed loop enclosed split ring biosensor with high field confinement for aqueous and blood-glucose measurements. Sci. Rep. 10, 4081 (2020).
doi: 10.1038/s41598-020-60806-9 pubmed: 32139716 pmcid: 7058086
Koirala, G. R. et al. Microfabricated passive resonator biochip for sensitive radiofrequency detection and characterization of glucose. RSC Adv. 8, 33072–33079 (2018).
doi: 10.1039/C8RA04243H pubmed: 35548156 pmcid: 9086445
Nguyen, T.-K. & Tseng, C.-H. A new microwave humidity sensor with near field self-injection-locked technology. IEEE Sens. J. 21, 19 (2021).
Nguyen, T.-K. & Tseng, C.-H. New radio-frequency liquid permittivity measurement system using filter-based microfluidic sensor. IEEE Sens. J. 23, 12 (2023).
Abdolrazzaghi, M. et al. Noninvasive glucose sensing in aqueous solutions using an active split ring resonator. IEEE Sens. 21(17), 18742–18755 (2021).
doi: 10.1109/JSEN.2021.3090050
Kazemi, N. In-human testing of a noninvasive continuous low energy microwave glucose senor with advanced machine learning capabilities. Biosens. Bioelectron. 241, 115668 (2023).
doi: 10.1016/j.bios.2023.115668 pubmed: 37774465
Kazemi, N. & Musilek, P. Enhancing microwave sensor performance with ultrathin Q-features using cycle GAN. IEEE Trans. Microwave Theory Tech. 70(12), 5369–5382 (2022).
Smolyaninov, I., Balzano, Q. & Kozyrev, A. B. Surface electromagnetic waves at seawater-air and seawater-seafloor interfaces. IEEE Open. J. Antennas Propag. 4, 51–59 (2023).
doi: 10.1109/OJAP.2022.3231885
Adhikari, K. K. & Kim, N. Y. Ultrahigh-sensitivity mediator-free biosensor based on a micro fabricated microwave resonator for the detection of micromolar glucose concentrations. IEEE Trans. Microwave Theory Tech. 64, 1 (2016).
Hassan, R. S., Lee, J. & Kim, S. A minimally invasive implantable sensor for continuous wireless glucose monitoring based on a passive resonator. IEEE Antennas Wirel. Propag. Lett. 19 (1), 124–128 (2020).
doi: 10.1109/LAWP.2019.2955176
Wangberg, R., Elser, J., Narimanov, E. E. & Podolskiy, V. A. Nonmagnetic nanocomposites for optical and infrared negative-refractive-index media. J. Opt. Soc. Amer. B Opt. Phys. 23 (3), 498–505 (2006).
doi: 10.1364/JOSAB.23.000498
Prince, M. E. et al. Effects of TiO2 nanoparticles on the dielectric and electromagnetic shielding performance of PVA/POM hybrid nanocomposites. Polymer-Plastics Tech. Mat. 63(14), 1874–1886 (2024).

Auteurs

Abhishek Kandwal (A)

School of Physics and Materials Science, Shoolini University, Bajhol, Solan, H.P, 173229, India. abhishekandwal@gmail.com.
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. abhishekandwal@gmail.com.
Faculty of Engineering and Quantity Surveying, INTI International University, Nilai, 71800, Malaysia. abhishekandwal@gmail.com.

Sudershan Dutt (S)

School of Physics and Materials Science, Shoolini University, Bajhol, Solan, H.P, 173229, India.

Louis W Y Liu (LWY)

Faculty of Engineering, Vietnamese German University, Ben Cát, 75000, Vietnam.

Zedong Nie (Z)

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. zd.nie@siat.ac.cn.

Rohit Jasrotia (R)

School of Physics and Materials Science, Shoolini University, Bajhol, Solan, H.P, 173229, India.
Center for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, Punjab, 140401, India.
Department of Physics, Graphic Era (Deemed to be University), Dehradun, 248002, India.

Choon Kit Chan (CK)

Faculty of Engineering and Quantity Surveying, INTI International University, Nilai, 71800, Malaysia.

Ali M Almuhlafi (AM)

Electrical Engineering Department, King Saud University, 11421, Riyadh, Saudi Arabia.

Hamsakutty Vettikalladi (H)

Electrical Engineering Department, King Saud University, 11421, Riyadh, Saudi Arabia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH