A single-center analysis of clonal transmission of carbapenem-resistant Acinetobacter baumannii among intensive care unit patients during the COVID-19 pandemic.
Humans
Acinetobacter baumannii
/ drug effects
Intensive Care Units
Carbapenems
/ pharmacology
Acinetobacter Infections
/ epidemiology
COVID-19
/ epidemiology
Anti-Bacterial Agents
/ pharmacology
Male
Iran
/ epidemiology
Female
Middle Aged
Microbial Sensitivity Tests
SARS-CoV-2
/ genetics
Pandemics
Drug Resistance, Multiple, Bacterial
/ genetics
Adult
Aged
beta-Lactamases
/ genetics
COVID-19
Carbapenem-Resistant Acinetobacter baumannii
Dendrogram
ESBL
MBL
MLVA
Minimum spanning tree
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 10 2024
29 10 2024
Historique:
received:
07
12
2023
accepted:
21
10
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
Carbapenem-Resistant Acinetobacter baumannii (CRAB) outbreak in intensive care units (ICUs) is a significant problem for healthcare facilities. In this study, we aimed to investigate the occurrence of CRAB isolates among ICU-admitted patients during the three waves of the COVID-19 pandemic in Iran using Multiple-Locus Variable Number Tandem-Repeat Analysis (MLVA). We obtained 50 (A) baumannii isolates from tracheal aspirate and blood culture samples. In the disc diffusion method, all isolates were cefotaxime, ceftriaxone, and cefepime-resistant, while 98% (49/50) of isolates were resistant to piperacillin, piperacillin-tazobactam, ceftazidime, and ciprofloxacin. Levofloxacin and tobramycin resistance was found in 76% (38/50) of isolates. In the microbroth dilution test all isolates were resistant to imipenem, 98% (49/50) to meropenem, 68% (34/50) to colistin, and 20% (10/50) to polymyxin (B) Based on the PCR findings, all isolates harbored bla
Identifiants
pubmed: 39468199
doi: 10.1038/s41598-024-77238-4
pii: 10.1038/s41598-024-77238-4
doi:
Substances chimiques
Carbapenems
0
Anti-Bacterial Agents
0
beta-Lactamases
EC 3.5.2.6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25897Informations de copyright
© 2024. The Author(s).
Références
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