Analysis of ventricular repolarization parameters and heart rate variability in obesity: a comparative study.
Cardiac autonomic neuropathy
Cardiac remodeling
Electrocardiography
Heart rate variability
Obesity
Ventricular repolarization
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
28 10 2024
28 10 2024
Historique:
received:
28
06
2024
accepted:
15
10
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
Obesity is associated with dysfunctional electrocardiographic and cardiac autonomic parameters, which may lead to increased cardiovascular morbidity. Novel electrocardiographic repolarization markers such as Tpeak-Tend (Tpe) interval have not yet been deeply studied in obese patients. We aimed to investigate the association between ventricular repolarization parameters and heart rate variability (HRV) and how they are affected by changes occurring in the cardiac autonomic nervous system. Ninety subjects categorized by Southeast Asian BMI (kg/m
Identifiants
pubmed: 39468214
doi: 10.1038/s41598-024-76580-x
pii: 10.1038/s41598-024-76580-x
doi:
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
25855Informations de copyright
© 2024. The Author(s).
Références
Poirier, P. & Eckel, R. H. Obesity and cardiovascular disease. Curr. Atheroscler Rep. 4(6), 448–453 (2002).
pubmed: 12361492
doi: 10.1007/s11883-002-0049-8
Alpert, M. A., Omran, J. & Bostick, B. P. Effects of obesity on cardiovascular hemodynamics, cardiac morphology, and ventricular function. Curr. Obes. Rep. 5(4), 424–434 (2016).
pubmed: 27744513
doi: 10.1007/s13679-016-0235-6
Lazzarin, T. et al. Role of nutrients and foods in attenuation of cardiac remodeling through oxidative stress pathways. Antioxid. (Basel). 11(10), 2064 (2022).
doi: 10.3390/antiox11102064
Shimizu, M. et al. T-peak to T-end interval may be a better predictor of high-risk patients with hypertrophic cardiomyopathy associated with a cardiac troponin I mutation than QT dispersion. Clin. Cardiol. 25(7), 335–339 (2002).
pubmed: 12109867
doi: 10.1002/clc.4950250706
Yamaguchi, M. et al. T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: A new index for arrhythmogenicity. Clin. Sci. Lond. Engl. 1979. 105(6), 671–676 (2003).
Locati, E. T., Bagliani, G. & Padeletti, L. Normal ventricular repolarization and QT interval. Card Electrophysiol. Clin. 9(3), 487–513 (2017).
pubmed: 28838552
doi: 10.1016/j.ccep.2017.05.007
Guzzardi, M. A., Iozzo, P. Fatty & heart cardiac damage, and inflammation. Rev. Diabet. Stud. RDS. 8(3), 403–417 (2011).
pubmed: 22262077
doi: 10.1900/RDS.2011.8.403
Patel, K. H. K. et al. Increasing adiposity is associated with QTc interval prolongation and increased ventricular arrhythmic risk in the context of metabolic dysfunction: results from the UK Biobank. Front. Cardiovasc. Med. 9, 939156 (2022).
pubmed: 35845082
pmcid: 9277510
doi: 10.3389/fcvm.2022.939156
Omran, J., Bostick, B. P., Chan, A. K. & Alpert, M. A. Obesity and ventricular repolarization: A comprehensive review. Prog Cardiovasc. Dis. 61(2), 124–135 (2018).
pubmed: 29698642
doi: 10.1016/j.pcad.2018.04.004
Jackman, W. M. et al. The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis. Prog Cardiovasc. Dis. 31(2), 115–172 (1988).
pubmed: 3047813
doi: 10.1016/0033-0620(88)90014-X
O’Neal, W. T. et al. Association between QT-Interval components and sudden Cardiac death: the ARIC Study (Atherosclerosis Risk in communities). Circ. Arrhythm. Electrophysiol. 10(10), (2017).
Wulsin, L. R., Horn, P. S., Perry, J. L., Massaro, J. M. & D’Agostino, R. B. Autonomic imbalance as a predictor of metabolic risks, cardiovascular disease, diabetes, and mortality. J. Clin. Endocrinol. Metab. 100(6), 2443–2448 (2015).
pubmed: 26047073
doi: 10.1210/jc.2015-1748
Shen, M. J. & Zipes, D. P. Role of the autonomic nervous system in modulating Cardiac Arrhythmias. Circ. Res. 114(6), 1004–1021 (2014).
pubmed: 24625726
doi: 10.1161/CIRCRESAHA.113.302549
Magnano, A. R., Holleran, S., Ramakrishnan, R., Reiffel, J. A. & Bloomfield, D. M. Autonomic nervous system influences on qt interval in normal subjects. J. Am. Coll. Cardiol. 39(11), 1820–1826 (2002).
pubmed: 12039498
doi: 10.1016/S0735-1097(02)01852-1
Yadav, R. L. et al. Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD. Diabetes Metab Syndr Obes Targets Ther. 10, 57–64 (2017).
Vinik, A. I., Maser, R. E., Mitchell, B. D. & Freeman, R. Diabetic autonomic neuropathy. Diabetes Care. 26(5), 1553–1579 (2003).
pubmed: 12716821
doi: 10.2337/diacare.26.5.1553
Benichou, T. et al. Heart rate variability in type 2 diabetes mellitus: A systematic review and meta–analysis. PLOS ONE. 13(4), e0195166 (2018).
pubmed: 29608603
pmcid: 5880391
doi: 10.1371/journal.pone.0195166
Pop-Busui, R. et al. Diabetic neuropathy: A position statement by the American Diabetes Association. Diabetes Care. 40(1), 136–154 (2017).
pubmed: 27999003
doi: 10.2337/dc16-2042
Abbas, R. et al. Sudden cardiac death in young individuals: A current review of evaluation, screening and prevention. J. Clin. Med. Res. 15(1), 1–9 (2023).
pubmed: 36755763
pmcid: 9881489
doi: 10.14740/jocmr4823
Hussain, G. & Farooque, I. Effect of obesity on electrocardiographic parameters of ventricular repolarization in healthy adults. J. Evid. Based Med. Healthc. 4(95), 5915–5920 (2017).
doi: 10.18410/jebmh/2017/1193
Misra, A. et al. Consensus statement for diagnosis of obesity, abdominal obesity and the metabolic syndrome for Asian indians and recommendations for physical activity, medical and surgical management. J. Assoc. Physicians India. 57, 163–170 (2009).
pubmed: 19582986
Mozos, I. & Filimon, L. QT and tpeak-tend intervals in shift workers. J. Electrocardiol. 46(1), 60–65 (2013).
pubmed: 23312361
doi: 10.1016/j.jelectrocard.2012.10.014
Baschieri, F. & Cortelli, P. Circadian rhythms of cardiovascular autonomic function: physiology and clinical implications in neurodegenerative diseases. Auton. Neurosci. Basic. Clin. 217, 91–101 (2019).
doi: 10.1016/j.autneu.2019.01.009
Li, Z. D. et al. Association between ventricular repolarization variables and cardiac diastolic function: A cross-sectional study of a healthy Chinese population. World J. Clin. Cases. 7(8), 940–950 (2019).
pubmed: 31119139
pmcid: 6509266
doi: 10.12998/wjcc.v7.i8.940
Emori, T. & Antzelevitch, C. Cellular basis for complex T waves and arrhythmic activity following combined I(kr) and I(Ks) block. J. Cardiovasc. Electrophysiol. 12(12), 1369–1378 (2001).
pubmed: 11797994
doi: 10.1046/j.1540-8167.2001.01369.x
Dykiert, I. A. et al. The effect of obesity on repolarization and other ECG parameters. J. Clin. Med. 13(12), 3587 (2024).
pubmed: 38930116
pmcid: 11205044
doi: 10.3390/jcm13123587
Panikkath, R. et al. Prolonged tpeak-to-tend interval on the resting ECG is associated with increased risk of sudden cardiac death. Circ. Arrhythm. Electrophysiol. 4(4), 441–447 (2011).
pubmed: 21593198
pmcid: 3157547
doi: 10.1161/CIRCEP.110.960658
Cardiovascular diseases (CVDs). [Internet]. [cited 2024 Aug 30]. https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds ).
Poliakova, N. et al. Influence of obesity indices, metabolic parameters and age on cardiac autonomic function in abdominally obese men. Metabolism. 61(9), 1270–1279 (2012).
pubmed: 22444779
doi: 10.1016/j.metabol.2012.02.006
Shaffer, F. & Ginsberg, J. P. An overview of heart rate variability metrics and norms. Front. Public. Health. 5, 258 (2017).
pubmed: 29034226
pmcid: 5624990
doi: 10.3389/fpubh.2017.00258
Kleiger, R. E., Miller, J. P., Bigger, J. T. & Moss, A. J. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol. 59(4), 256–62 (1987).
Kim, J. A. et al. Heart rate variability and obesity indices: Emphasis on the response to noise and standing. J. Am. Board. Fam Pract. 18(2), 97–103 (2005).
pubmed: 15798138
doi: 10.3122/jabfm.18.2.97
Windham, B. G. et al. The relationship between heart rate variability and adiposity differs for central and overall adiposity. J. Obes. 2012, e149516 (2012).
doi: 10.1155/2012/149516
Malik, M. et al. Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Eur. Heart J. 17(3), 354–381 (1996).
doi: 10.1093/oxfordjournals.eurheartj.a014868
Farah, B. Q., Prado, W. L., do, Tenório, T. R. & dos Ritti-Dias, S. Heart rate variability and its relationship with central and general obesity in obese normotensive adolescents. Einstein Sao Paulo Braz. 11(3), 285–290 (2013).
doi: 10.1590/S1679-45082013000300005
SM, R. R. Y. V., N. & CG, M. S. Heart rate variability in Indian obese young adults. PJP. 8(1), 39–34 (2018).
Shaffer, F., McCraty, R. & Zerr, C. L. A healthy heart is not a metronome: An integrative review of the heart’s anatomy and heart rate variability. Front. Psychol. 5, 1040 (2014).
pubmed: 25324790
pmcid: 4179748
doi: 10.3389/fpsyg.2014.01040
Thayer, J. F., Yamamoto, S. S. & Brosschot, J. F. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int. J. Cardiol. 141(2), 122–131 (2010).
pubmed: 19910061
doi: 10.1016/j.ijcard.2009.09.543
Maule, S. et al. Prolonged QT interval and reduced heart rate variability in patients with uncomplicated essential hypertension. Hypertens. Res. Off J. Jpn Soc. Hypertens. 31(11), 2003–2010 (2008).
doi: 10.1291/hypres.31.2003
Cha, S. A. Heart rate-corrected QT interval prolongation is associated with decreased heart rate variability in patients with type 2 diabetes. Med. (Baltim). 101(45), e31511 (2022).
doi: 10.1097/MD.0000000000031511
Roden, D. M. & Spooner, P. M. Inherited long QT syndromes: A paradigm for understanding arrhythmogenesis. J. Cardiovasc. Electrophysiol. 10(12), 1664–1683 (1999).
pubmed: 10636197
doi: 10.1111/j.1540-8167.1999.tb00231.x
Peters, R. W., Byington, R. P., Barker, A. & Yusuf, S. Prognostic value of prolonged ventricular repolarization following myocardial infarction: The BHAT experience. The BHAT Study Group. J. Clin. Epidemiol. 43(2), 167–172 (1990).
pubmed: 2406377
doi: 10.1016/0895-4356(90)90180-W
Marfella, R. et al. The effect of acute hyperglycaemia on QTc duration in healthy man. Diabetologia. 43(5), 571–575 (2000).
pubmed: 10855531
doi: 10.1007/s001250051345
Dekker, J. M. et al. QTc duration is associated with levels of insulin and glucose intolerance. The Zutphen Elderly Study. Diabetes. 45(3), 376–380 (1996).
pubmed: 8593946
doi: 10.2337/diab.45.3.376
Rautaharju, P. M., Park, L. P., Chaitman, B. R., Rautaharju, F. & Zhang, Z. M. The Novacode criteria for classification of ECG abnormalities and their clinically significant progression and regression. J. Electrocardiol. 31(3), 157–187 (1998).
pubmed: 9682893
doi: 10.1016/S0022-0736(98)90132-7
Gastaldelli, A., Emdin, M., Conforti, F., Camastra, S. & Ferrannini, E. Insulin prolongs the QTc interval in humans. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279(6), R2022–2025 (2000).
pubmed: 11080065
doi: 10.1152/ajpregu.2000.279.6.R2022
Carella, M. J. et al. Obesity, adiposity, and lengthening of the QT interval: Improvement after weight loss. Int. J. Obes. Relat. Metab. Disord J. Int. Assoc. Study Obes. 20(10), 938–942 (1996).