Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β
ErbB Receptors
/ metabolism
Humans
Receptors, Adrenergic, beta-2
/ metabolism
Transcriptional Activation
/ drug effects
Receptors, Dopamine D2
/ metabolism
Phosphorylation
/ drug effects
HEK293 Cells
Signal Transduction
/ drug effects
G-Protein-Coupled Receptor Kinase 2
/ metabolism
Quinazolines
/ pharmacology
G-Protein-Coupled Receptor Kinases
/ metabolism
Tyrphostins
/ pharmacology
Epidermal Growth Factor
/ metabolism
Arrestin
Desensitization
Deubiquitination
EGFR
GPCR
Transactivation
Journal
Cellular & molecular biology letters
ISSN: 1689-1392
Titre abrégé: Cell Mol Biol Lett
Pays: England
ID NLM: 9607427
Informations de publication
Date de publication:
28 Oct 2024
28 Oct 2024
Historique:
received:
04
06
2024
accepted:
11
10
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of receptor tyrosine kinases. Contrary to the typical assertions, our findings demonstrate that EGFR transactivation contributes to the desensitization of GPCRs. Repeated agonist stimulation of certain GPCRs enhanced EGFR transactivation, triggering a series of cellular events associated with GPCR desensitization. This effect was observed in receptors undergoing desensitization (D
Identifiants
pubmed: 39468452
doi: 10.1186/s11658-024-00652-z
pii: 10.1186/s11658-024-00652-z
doi:
Substances chimiques
ErbB Receptors
EC 2.7.10.1
Receptors, Adrenergic, beta-2
0
Receptors, Dopamine D2
0
G-Protein-Coupled Receptor Kinase 2
EC 2.7.11.16
Quinazolines
0
G-Protein-Coupled Receptor Kinases
EC 2.7.11.16
Tyrphostins
0
GRK2 protein, human
EC 2.7.11.15
G-protein-coupled receptor kinase 6
EC 2.7.11.16
RTKI cpd
170449-18-0
Epidermal Growth Factor
62229-50-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
132Informations de copyright
© 2024. The Author(s).
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