Wnt/β-catenin signaling pathway: proteins' roles in osteoporosis and cancer diseases and the regulatory effects of natural compounds on osteoporosis.
Natural compounds
Osteoblasts
Osteoporosis
Wnt/β-catenin signaling pathway
Journal
Molecular medicine (Cambridge, Mass.)
ISSN: 1528-3658
Titre abrégé: Mol Med
Pays: England
ID NLM: 9501023
Informations de publication
Date de publication:
28 Oct 2024
28 Oct 2024
Historique:
received:
17
05
2024
accepted:
09
10
2024
medline:
29
10
2024
pubmed:
29
10
2024
entrez:
29
10
2024
Statut:
epublish
Résumé
Osteoblasts are mainly derived from mesenchymal stem cells in the bone marrow. These stem cells can differentiate into osteoblasts, which have the functions of secreting bone matrix, promoting bone formation, and participating in bone remodeling. The abnormality of osteoblasts can cause a variety of bone-related diseases, including osteoporosis, delayed fracture healing, and skeletal deformities. In recent years, with the side effects caused by the application of PTH drugs, biphosphonate drugs, and calmodulin drugs, people have carried out more in-depth research on the mechanism of osteoblast differentiation, and are actively looking for natural compounds for the treatment of osteoporosis. The Wnt/β-catenin signaling pathway is considered to be one of the important pathways of osteoblast differentiation, and has become an important target for the treatment of osteoporosis. The Wnt/β-catenin signaling pathway, whether its activation is enhanced or its expression is weakened, will cause a variety of diseases including tumors. This review will summarize the effect of Wnt/β-catenin signaling pathway on osteoblast differentiation and the correlation between the related proteins in the pathway and human diseases. At the same time, the latest research progress of natural compounds targeting Wnt/β-catenin signaling pathway against osteoporosis is summarized.
Identifiants
pubmed: 39468464
doi: 10.1186/s10020-024-00957-x
pii: 10.1186/s10020-024-00957-x
doi:
Substances chimiques
Biological Products
0
beta Catenin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
193Subventions
Organisme : the National Natural Science Foundation of China
ID : 82260181
Organisme : Natural Science Basic Research Program of Shaanxi Province
ID : 2022JZ-43
Organisme : Medical Research Project of Xi'an Science and Technology Bureau
ID : 24YXYJ0102
Organisme : Medical Research Project of Xi'an Science and Technology Bureau
ID : 24YXYJ0006
Informations de copyright
© 2024. The Author(s).
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