Effect of wound dressing porosity and exudate viscosity on the exudate absorption:

3D printed hydrogel Computational modeling Exudate absorption Pore size Viscosity Wound dressing

Journal

International journal of pharmaceutics: X
ISSN: 2590-1567
Titre abrégé: Int J Pharm X
Pays: Netherlands
ID NLM: 101753452

Informations de publication

Date de publication:
Dec 2024
Historique:
received: 31 08 2024
revised: 28 09 2024
accepted: 01 10 2024
medline: 29 10 2024
pubmed: 29 10 2024
entrez: 29 10 2024
Statut: epublish

Résumé

Exudate absorption is a key parameter for proper wound dressing performance. Unlike standardized tests that consider exudate viscosity close to that of water, patients' exudates vary greatly in composition and, therefore, viscosity. This work aimed to investigate the effects of exudate viscosity and pore size of hydrogel-like dressings on the exudate absorption rate to establish rational criteria for the design of dressings that can meet the personalized needs of wound treatment. Computer-aided design (CAD) was used for Digital Light Processing (DLP) 3D printing of hydrogels with 0%, 30% and 60% porosity. The hydrogels were characterized in detail, and the absorption of two simulated exudate fluids (SEFs) was video-recorded. The same CAD files were used to develop

Identifiants

pubmed: 39469079
doi: 10.1016/j.ijpx.2024.100288
pii: S2590-1567(24)00060-4
pmc: PMC11513483
doi:

Types de publication

Journal Article

Langues

eng

Pagination

100288

Informations de copyright

© 2024 The Author(s). Published by Elsevier B.V.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Alejandro Seijo-Rabina (A)

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Santiago Paramés-Estevez (S)

Group of NonLinear Physics, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Galician Center for Mathematical Research and Technology (CITMAga), 15782 Santiago de Compostela, Spain.

Angel Concheiro (A)

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Alberto Pérez-Muñuzuri (A)

Group of NonLinear Physics, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Galician Center for Mathematical Research and Technology (CITMAga), 15782 Santiago de Compostela, Spain.

Carmen Alvarez-Lorenzo (C)

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Classifications MeSH