Internal regulation between constitutively expressed T cell co-inhibitory receptors BTLA and CD5 and tolerance in recent thymic emigrants.

Animals Receptors, Immunologic / metabolism Mice Thymus Gland / metabolism CD5 Antigens / metabolism Programmed Cell Death 1 Receptor / metabolism Immune Tolerance Gene Expression Regulation Mice, Knockout Signal Transduction
BTLA CD5 T cells autoimmunity recent thymic emigrants tolerance

Journal

Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 29 10 2024
Statut: ppublish

Résumé

Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expressed co-inhibitors and when they are needed is unknown. Deletion of

Identifiants

DOI: 10.1098/rsob.240178 PMID: 39471840
pubmed: 39471840
doi: 10.1098/rsob.240178
doi:

Substances chimiques

Receptors, Immunologic 0
CD5 Antigens 0
BTLA protein, mouse 0
Programmed Cell Death 1 Receptor 0
Cd5 protein, mouse 0
Pdcd1 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

240178

Subventions

Organisme : Natural Sciences and Engineering Research Council of Canada
Organisme : NIH HHS
Pays : United States
Organisme : CIHR
Pays : Canada

Auteurs

Adeolu O Adegoke (AO)

Department of Surgery, University of Alberta, Edmonton, AB, Canada.
ORCID: 0000-0003-0886-9678

Govindarajan Thangavelu (G)

Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Alberta Diabetes and Transplant Institutes, University of Alberta, Edmonton, AB, Canada.

Ting-Fang Chou (TF)

La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Marcos I Petersen (MI)

Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

Kiyokazu Kakugawa (K)

Laboratory for Immune Crosstalk, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan.

Julia F May (JF)

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

Kevin Joannou (K)

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

Qingyang Wang (Q)

La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

Kristofor K Ellestad (KK)

Alberta Diabetes and Transplant Institutes, University of Alberta, Edmonton, AB, Canada.
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.

Louis Boon (L)

JJP Biologics, Warsaw, Poland.

Peter A Bretscher (PA)

Department of Microbiology and Immunology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Hilde Cheroutre (H)

La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Laboratory for Immune Crosstalk, RIKEN Center for Integrative Medical Sciences, 1-7-22 Suehiro, Tsurumi-ku, Yokohama 230-0045, Japan.

Mitchell Kronenberg (M)

La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Department of Molecular Biology, University of California San Diego, La Jolla, CA 92093, USA.
ORCID: 0000-0001-6318-6445

Troy A Baldwin (TA)

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
ORCID: 0000-0002-0122-3746

Colin C Anderson (CC)

Department of Surgery, University of Alberta, Edmonton, AB, Canada.
Alberta Diabetes and Transplant Institutes, University of Alberta, Edmonton, AB, Canada.
Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
ORCID: 0000-0003-1733-4237

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Internal regulation between constitutively...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Internal regulation between constitutively...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Internal regulation between constitutively...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Thymus (glande) › Internal regulation between constitutively...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD5 › Internal regulation between constitutively...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Internal regulation between constitutively...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunomodulation › Tolérance immunitaire › Internal regulation between constitutively...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Internal regulation between constitutively...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Internal regulation between constitutively...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Internal regulation between constitutively...