Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4

Humans HIV-1 / genetics HIV Infections / genetics CD4-Positive T-Lymphocytes / virology CD4 Lymphocyte Count Viral Load
HIV/AIDS bioinformatics infectious disease dynamics

Journal

Journal of the Royal Society, Interface
ISSN: 1742-5662
Titre abrégé: J R Soc Interface
Pays: England
ID NLM: 101217269

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 29 10 2024
Statut: ppublish

Résumé

HIV-1 transmission precipitates a stringent genetic bottleneck, with 75% of new infections initiated by a single genetic variant. Where multiple variants initiate infection, recipient set point viral load (SpVL) and the rate of CD4

Identifiants

DOI: 10.1098/rsif.2024.0255 PMID: 39471873
pubmed: 39471873
doi: 10.1098/rsif.2024.0255
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

20240255

Subventions

Organisme : European Research Council
Pays : International
Organisme : Medical Research Council
Pays : United Kingdom

Auteurs

James Baxter (J)

Usher Institute, Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-6598-1784

Ch Julián Villabona-Arenas (CJ)

Faculty of Epidemiology and Population Health, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
ORCID: 0000-0001-9928-3968

Robin N Thompson (RN)

Mathematical Institute, University of Oxford, Oxford OX2 6GG, UK.
ORCID: 0000-0001-8545-5212

Stéphane Hué (S)

Faculty of Epidemiology and Population Health, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
ORCID: 0000-0002-8580-6905

Roland R Regoes (RR)

Department of Environmental Systems Science, Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland.
ORCID: 0000-0001-8319-5293

Roger D Kouyos (RD)

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-9220-8348

Huldrych F Günthard (HF)

Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-1142-6723

Jan Albert (J)

Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden.
ORCID: 0000-0001-9020-0521

Andrew Leigh Brown (A)

Institute of Evolutionary Ecology, The University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0002-5700-3128

Katherine E Atkins (KE)

Usher Institute, Edinburgh Medical School, The University of Edinburgh, Edinburgh, UK.
Faculty of Epidemiology and Population Health, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
ORCID: 0000-0001-5250-0558

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reconciling founder variant multiplicity of...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › Reconciling founder variant multiplicity of...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › Reconciling founder variant multiplicity of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Reconciling founder variant multiplicity of...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémogramme › Numération des leucocytes › Numération des lymphocytes › Numération des lymphocytes CD4 › Reconciling founder variant multiplicity of...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Reconciling founder variant multiplicity of...