Methylmalonic acid induces metabolic abnormalities and exhaustion in CD8
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
29 Oct 2024
29 Oct 2024
Historique:
received:
28
02
2024
accepted:
08
10
2024
revised:
04
10
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
aheadofprint
Résumé
Systemic levels of methylmalonic acid (MMA), a byproduct of propionate metabolism, increase with age and MMA promotes tumor progression via its direct effects in tumor cells. However, the role of MMA in modulating the tumor ecosystem remains to be investigated. The proliferation and function of CD8
Identifiants
pubmed: 39472497
doi: 10.1038/s41388-024-03191-1
pii: 10.1038/s41388-024-03191-1
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : R00CA218686
Organisme : NCI NIH HHS
ID : T32 CA233399
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : P30CA006516
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : P30CA076292
Organisme : U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
ID : P01CA250984
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature Limited.
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