Pre-treatment metastatic biopsy: a step towards precision oncology for urothelial cancer.


Journal

Nature reviews. Urology
ISSN: 1759-4820
Titre abrégé: Nat Rev Urol
Pays: England
ID NLM: 101500082

Informations de publication

Date de publication:
29 Oct 2024
Historique:
accepted: 12 09 2024
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 30 10 2024
Statut: aheadofprint

Résumé

Early metastatic spread and clonal expansion of individual mutations result in a heterogeneous tumour landscape in metastatic urothelial cancer (mUC). Substantial molecular heterogeneity of common drug targets, such as membranous NECTIN4, FGFR3 mutations, PDL1 or immune phenotypes, has been documented between primary and metastatic tumours. However, translational and clinical studies frequently do not account for such heterogeneity and often investigate primary tumour samples that might not be representative in patients with mUC. We propose this as a potential factor for why many biomarkers for mUC have failed to be integrated into clinical practice. Fresh pre-treatment metastatic biopsies enable the capturing of prevailing tumour biology in real time. The characterization of metastatic tumour samples can improve response prediction to immunotherapy, the anti-NECTIN4 antibody-drug conjugate enfortumab vedotin and the FGFR inhibitor erdafitinib. Routine metastatic biopsy can thus improve the precision of identifying driver druggable alterations, thus improving treatment selection for patients with mUC.

Identifiants

pubmed: 39472646
doi: 10.1038/s41585-024-00951-2
pii: 10.1038/s41585-024-00951-2
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Niklas Klümper (N)

Department of Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany. niklas.kluemper@ukbonn.de.
Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany. niklas.kluemper@ukbonn.de.

Alexander Cox (A)

Department of Urology and Pediatric Urology, University Hospital Bonn, Bonn, Germany.

Gottfrid Sjödahl (G)

Department of Translational Medicine, Division of Urological Research, Lund University, Lund, Sweden.

Florian Roghmann (F)

Department of Urology, Marien Hospital, Ruhr-University Bochum, Herne, Germany.

Christian Bolenz (C)

Department of Urology and Paediatric Urology, University Hospital Ulm, University of Ulm, Ulm, Germany.

Arndt Hartmann (A)

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Viktor Grünwald (V)

Clinic for Internal Medicine (Tumour Research) and Clinic for Urology, Interdisciplinary Genitourinary Oncology at the West-German Cancer Center, Essen University Hospital, Essen, Germany.

Bishoy M Faltas (BM)

Department of Hematology/Oncology, Weill-Cornell Medicine, New York, NY, USA.

Michael Hölzel (M)

Institute of Experimental Oncology, University Hospital Bonn, Bonn, Germany.

Markus Eckstein (M)

Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Classifications MeSH