Femoral cartilage defects initiate from medial meniscus extrusion or tibial cartilage lesions and expand in knee osteoarthritis as revealed by 3D MRI analysis.
Humans
Middle Aged
Osteoarthritis, Knee
/ diagnostic imaging
Magnetic Resonance Imaging
/ methods
Female
Aged
Cartilage, Articular
/ diagnostic imaging
Adult
Menisci, Tibial
/ diagnostic imaging
Imaging, Three-Dimensional
/ methods
Femur
/ diagnostic imaging
Tibia
/ diagnostic imaging
Cross-Sectional Studies
Knee Joint
/ diagnostic imaging
3D MRI
Femoral cartilage
Knee
Medial meniscus extrusion
Osteoarthritis
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
29 10 2024
29 10 2024
Historique:
received:
19
07
2024
accepted:
16
10
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Knee osteoarthritis is characterized by articular cartilage wear, with its morphological progression not fully understood. This study aimed to elucidate factors contributing to femoral cartilage defects and their expansion in medial knee osteoarthritis, using a novel approach analyzing cross-sectional MRI data arranged by disease severity. From a cohort of 277 women in the Kanagawa Knee Study, we selected 17 knees that showed a cartilage area ratio < 0.99 in the posteromedial femoral cartilage region as the subjects for this study. The morphological relationships between femoral cartilage defects and menisci, as well as between femoral cartilage defects and tibial cartilage lesions, were investigated. Among subjects aged 30 to 79 years, the proportion was significantly higher in the 70-79 age group. In 11 cases, the outer edge of the cartilage defect was observed to coincide with the inner edge of the medial meniscus. Tibial cartilage lesions corresponded to femoral cartilage defects in 15 cases. Our 3D MRI analysis demonstrated that femoral cartilage defects were initially caused by either medial meniscus extrusion or kissing tibial cartilage lesions, with subsequent expansion of these defects resulting from the combined effects of ongoing medial meniscus extrusion and progressive tibial cartilage degeneration.Trial registration: UMIN, UMIN000032826; September 1, 2018.
Identifiants
pubmed: 39472689
doi: 10.1038/s41598-024-76725-y
pii: 10.1038/s41598-024-76725-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25937Subventions
Organisme : Japan Society for the Promotion of Science
ID : 22K09349
Informations de copyright
© 2024. The Author(s).
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