Triple immunostaining demonstrates the possible existence of segregated-nucleus-containing atypical monocytes in human primary myelofibrosis bone marrow: a case report.
Bone marrow
Case report
Immunohistochemistry
Monocyte
Primary myelofibrosis
Segregated-nucleus-containing atypical monocyte
Journal
Journal of medical case reports
ISSN: 1752-1947
Titre abrégé: J Med Case Rep
Pays: England
ID NLM: 101293382
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
08
03
2024
accepted:
03
09
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Segregated-nucleus-containing atypical monocytes have recently been identified in mice. Segregated-nucleus-containing atypical monocytes are thought to originate from the bone marrow and induce fibrosis in the drug-injured lung. The Lyc6c A 74-year-old Japanese male visited our hospital for clinical follow-up after total prostatectomy for prostatic cancer. Anemia, thrombocytosis, and elevated lactate dehydrogenase were suddenly observed in a periodic examination. CALR mutation type 2 (p.K385fs*47) was observed. The histological features of the patient's bone marrow were consistent with fibrotic primary myelofibrosis. We immunohistochemically studied the bone marrow in an attempt to identify a human counterpart to murine segregated-nucleus-containing atypical monocytes. We detected a few CD16 There is a possibility that human segregated-nucleus-containing atypical monocytes exist in the bone marrow of primary myelofibrosis patients and might be related to marrow fibrosis.
Sections du résumé
BACKGROUND
BACKGROUND
Segregated-nucleus-containing atypical monocytes have recently been identified in mice. Segregated-nucleus-containing atypical monocytes are thought to originate from the bone marrow and induce fibrosis in the drug-injured lung. The Lyc6c
CASE PRESENTATION
METHODS
A 74-year-old Japanese male visited our hospital for clinical follow-up after total prostatectomy for prostatic cancer. Anemia, thrombocytosis, and elevated lactate dehydrogenase were suddenly observed in a periodic examination. CALR mutation type 2 (p.K385fs*47) was observed. The histological features of the patient's bone marrow were consistent with fibrotic primary myelofibrosis. We immunohistochemically studied the bone marrow in an attempt to identify a human counterpart to murine segregated-nucleus-containing atypical monocytes. We detected a few CD16
CONCLUSION
CONCLUSIONS
There is a possibility that human segregated-nucleus-containing atypical monocytes exist in the bone marrow of primary myelofibrosis patients and might be related to marrow fibrosis.
Identifiants
pubmed: 39472997
doi: 10.1186/s13256-024-04844-1
pii: 10.1186/s13256-024-04844-1
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
510Informations de copyright
© 2024. The Author(s).
Références
J Exp Med. 2016 Aug 22;213(9):1723-40
pubmed: 27481130
Nature. 2017 Jan 5;541(7635):96-101
pubmed: 28002407
Intern Med. 2022;61(22):3323-3328
pubmed: 36385045
Mediterr J Hematol Infect Dis. 2018 Nov 01;10(1):e2018068
pubmed: 30416700
PLoS One. 2019 Sep 30;14(9):e0222912
pubmed: 31569199
Front Immunol. 2015 Jun 25;6:330
pubmed: 26124761
Front Immunol. 2017 Dec 20;8:1866
pubmed: 29326724
Nat Rev Immunol. 2006 Jun;6(6):433-46
pubmed: 16724098
PLoS One. 2017 Apr 26;12(4):e0176460
pubmed: 28445506
Clin Transl Med. 2015 Feb 07;4:2
pubmed: 25852818