Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): A 10-year Retrospective Review.

Journal

HGG advances
ISSN: 2666-2477
Titre abrégé: HGG Adv
Pays: United States
ID NLM: 101772885

Informations de publication

Date de publication:
28 Oct 2024
Historique:
received: 18 04 2024
revised: 24 10 2024
accepted: 24 10 2024
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 30 10 2024
Statut: aheadofprint

Résumé

The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 15-year retrospective review highlights the major findings for genotype phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the U.S. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.

Identifiants

DOI: 10.1016/j.xhgg.2024.100376 PMID: 39473183
pubmed: 39473183
pii: S2666-2477(24)00116-7
doi: 10.1016/j.xhgg.2024.100376
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100376

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Hridya Rao (H)

Department of Biobehavioral Health, Pennsylvania State University, University Park, PA.

Margaret C Weiss (MC)

Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL.

Jee Young Moon (JY)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.

Krista M Perreira (KM)

Department of Social Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.

Martha L Daviglus (ML)

Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL.

Robert Kaplan (R)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Kari E North (KE)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Maria Argos (M)

Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL; Department of Environmental Health, School of Public Health, Boston University, Boston, MA.

Lindsay Fernández-Rhodes (L)

Department of Biobehavioral Health, Pennsylvania State University, University Park, PA.

Tamar Sofer (T)

Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Medicine, Brigham and Women's Hospital, Boston, MA. Electronic address: tsofer@bidmc.harvard.edu.

Classifications MeSH