Clinical features of Chagas disease progression and severity.
Chagas cardiomyopathy
Chagas disease
Progression
Severity
Journal
Lancet regional health. Americas
ISSN: 2667-193X
Titre abrégé: Lancet Reg Health Am
Pays: England
ID NLM: 9918232503006676
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
received:
27
02
2024
revised:
31
05
2024
accepted:
18
06
2024
medline:
30
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Chagas disease, the most common form of nonischaemic cardiomyopathy globally, is one of the leading causes of morbidity and mortality in Latin America. Chagas cardiomyopathy has a wide clinical spectrum and prognosis, which is primarily determined by the severity of left ventricular dysfunction. Chagas disease also affects the brain, particularly manifesting as cardioembolic strokes and cognitive impairments. Disease progression is influenced by various factors such as anti-parasite treatments, host-parasite interactions, and other determinants. This review explores Chagas disease, covering clinical presentations, the range of severity of Chagas cardiomyopathy, and neurological manifestations. We investigate factors that influence the progression of cardiomyopathy, including anti-parasitic treatments, interactions between hosts and parasites, and the influence of social determinants on the course of the disease. This review analyses key prognostic factors associated with the progression and mortality of Chagas cardiomyopathy, offering insights into this potentially fatal illness.
Identifiants
pubmed: 39474468
doi: 10.1016/j.lana.2024.100832
pii: S2667-193X(24)00159-5
pmc: PMC11519696
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
100832Subventions
Organisme : NIAID NIH HHS
ID : K23 AI168583
Pays : United States
Informations de copyright
© 2024 The Authors.
Déclaration de conflit d'intérêts
C.B. has received royalties for Chagas disease topics from UpToDate (Wolters Kluwer Health). M.C.P.N., E.H.P., A.L.T., and I.M. have no conflicts of interest to declare.
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