PKCδ is an activator of neuronal mitochondrial metabolism that mediates the spacing effect on memory consolidation.

Animals Protein Kinase C-delta / metabolism Mitochondria / metabolism Neurons / metabolism Mushroom Bodies / metabolism Memory Consolidation / physiology Drosophila melanogaster / physiology Memory, Long-Term / physiology Drosophila Drosophila Proteins / metabolism
D. melanogaster Drosophila dopamine energy long-term memory mushroom body neuroscience

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
30 Oct 2024
Historique:
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 30 10 2024
Statut: epublish

Résumé

Relevance-based selectivity and high energy cost are two distinct features of long-term memory (LTM) formation that warrant its default inhibition. Spaced repetition of learning is a highly conserved cognitive mechanism that can lift this inhibition. Here, we questioned how the spacing effect integrates experience selection and energy efficiency at the cellular and molecular levels. We showed in

Identifiants

DOI: 10.7554/eLife.92085 PMID: 39475218
pubmed: 39475218
doi: 10.7554/eLife.92085
pii: 92085
doi:
pii:

Substances chimiques

Protein Kinase C-delta EC 2.7.11.13
Drosophila Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : European Research Council
ID : AdG-741550
Pays : International
Organisme : Agence Nationale de la Recherche
ID : 20-CE92-0047-01
Organisme : Fondation pour la Recherche Médicale
ID : FDT202304016704
Organisme : Region Ile-de-France
ID : DIM ELICIT

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2024, Comyn et al.

Déclaration de conflit d'intérêts

TC, TP, AP, PP No competing interests declared

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Auteurs

Typhaine Comyn (T)

Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.

Thomas Preat (T)

Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.

Alice Pavlowsky (A)

Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.
ORCID: 0000-0001-6873-0577

Pierre-Yves Plaçais (PY)

Energy & Memory, Brain Plasticity Unit, CNRS, ESPCI Paris, PSL Research University, Paris, France.
ORCID: 0000-0001-8426-4465

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Protéine kinase C › Protein kinase C-delta › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Cellules › Neurones › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Structures anatomiques de l'animal › Corps pédonculés › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire à long terme › Consolidation de la mémoire › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire à long terme › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › PKCδ is an activator of neuronal mitochondrial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › PKCδ is an activator of neuronal mitochondrial...