NPR1 promotes cisplatin resistance by inhibiting PARL-mediated mitophagy-dependent ferroptosis in gastric cancer.
Chemoresistance
Ferroptosis
Gastric Cancer
Mitophagy
NPR1
PARL
Ubiquitination
Journal
Cell biology and toxicology
ISSN: 1573-6822
Titre abrégé: Cell Biol Toxicol
Pays: Switzerland
ID NLM: 8506639
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
09
04
2024
accepted:
16
10
2024
medline:
31
10
2024
pubmed:
30
10
2024
entrez:
30
10
2024
Statut:
epublish
Résumé
Cisplatin-based chemotherapy serves as the standard of care for individuals with advanced stages of gastric cancer. Nevertheless, the emergence of chemoresistance in GC has detrimental impacts on prognosis, yet the underlying mechanisms governing this phenomenon remain elusive. Level of mitophagy and ferroptosis of GC cells were detected by fluorescence, flow cytometry, GSH, MDA, Fe
Identifiants
pubmed: 39476297
doi: 10.1007/s10565-024-09931-z
pii: 10.1007/s10565-024-09931-z
doi:
Substances chimiques
Cisplatin
Q20Q21Q62J
Antineoplastic Agents
0
Receptors, Atrial Natriuretic Factor
EC 4.6.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
93Subventions
Organisme : Anhui Provincial Health Commission Provincial Financial Key Projects
ID : AHWJ2023A10126
Organisme : Natural Science Research Project of Higher Education in Anhui Province
ID : KJ2021A0857
Organisme : Natural Science Research Project of Higher Education in Anhui Province
ID : 2023AH051771
Organisme : Natural Science Foundation of China
ID : 82372707
Informations de copyright
© 2024. The Author(s).
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