Combined analysis of the MF18-02/MF18-03 NEOSENTITURK studies: ypN-positive disease does not necessitate axillary lymph node dissection in patients with breast cancer with a good response to neoadjuvant chemotherapy as long as radiotherapy is provided.

axillary lymph node dissection breast cancer neoadjuvant chemotherapy sentinel lymph node biopsy targeted axillary dissection

Journal

Cancer
ISSN: 1097-0142
Titre abrégé: Cancer
Pays: United States
ID NLM: 0374236

Informations de publication

Date de publication:
30 Oct 2024
Historique:
revised: 21 07 2024
received: 04 03 2024
accepted: 24 07 2024
medline: 30 10 2024
pubmed: 30 10 2024
entrez: 30 10 2024
Statut: aheadofprint

Résumé

The omission of axillary lymph node dissection (ALND) remains controversial for patients with residual axillary disease after neoadjuvant chemotherapy (NAC), regardless of the residual burden. This study evaluated the oncologic safety and factors associated with outcomes in patients with residual axillary disease. These patients were treated solely with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD), without ALND, after NAC. A joint analysis of two different multicenter cohorts-the retrospective cohort registry MF18-02 and the prospective observational cohort registry MF18-03 (NCT04250129)-was conducted between January 2004 and August 2022. All patients received regional nodal irradiation. Five hundred and one patients with cT1-4, N1-3M0 disease who achieved a complete clinical response to NAC underwent either SLNB alone (n = 353) or TAD alone (n = 148). At a median follow-up of 42 months, axillary and locoregional recurrence rates were 0.4% (n = 2) and 0.8% (n = 4). No significant difference was found in disease-free survival (DFS) and disease-specific survival (DSS) rates between patients undergoing TAD alone versus SLNB alone, those with breast positive versus negative pathologic complete response, SLN methodology, total metastatic LN of one versus ≥2, or metastasis types as isolated tumor cells with micrometastases versus macrometastases. In the multivariate analysis, patients with nonluminal pathology were more likely to have a worse DFS and DSS, respectively, without an increased axillary recurrence. The omission of ALND can be safely considered for patients who achieve a complete clinical response after NAC, even if residual disease is detected by pathologic examination. Provided that adjuvant radiotherapy is administered, neither the SLNB method nor the number of excised LNs significantly affects oncologic outcomes.

Sections du résumé

BACKGROUND BACKGROUND
The omission of axillary lymph node dissection (ALND) remains controversial for patients with residual axillary disease after neoadjuvant chemotherapy (NAC), regardless of the residual burden. This study evaluated the oncologic safety and factors associated with outcomes in patients with residual axillary disease. These patients were treated solely with sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD), without ALND, after NAC.
METHODS METHODS
A joint analysis of two different multicenter cohorts-the retrospective cohort registry MF18-02 and the prospective observational cohort registry MF18-03 (NCT04250129)-was conducted between January 2004 and August 2022. All patients received regional nodal irradiation.
RESULTS RESULTS
Five hundred and one patients with cT1-4, N1-3M0 disease who achieved a complete clinical response to NAC underwent either SLNB alone (n = 353) or TAD alone (n = 148). At a median follow-up of 42 months, axillary and locoregional recurrence rates were 0.4% (n = 2) and 0.8% (n = 4). No significant difference was found in disease-free survival (DFS) and disease-specific survival (DSS) rates between patients undergoing TAD alone versus SLNB alone, those with breast positive versus negative pathologic complete response, SLN methodology, total metastatic LN of one versus ≥2, or metastasis types as isolated tumor cells with micrometastases versus macrometastases. In the multivariate analysis, patients with nonluminal pathology were more likely to have a worse DFS and DSS, respectively, without an increased axillary recurrence.
CONCLUSIONS CONCLUSIONS
The omission of ALND can be safely considered for patients who achieve a complete clinical response after NAC, even if residual disease is detected by pathologic examination. Provided that adjuvant radiotherapy is administered, neither the SLNB method nor the number of excised LNs significantly affects oncologic outcomes.

Identifiants

pubmed: 39476303
doi: 10.1002/cncr.35610
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.

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Auteurs

Mahmut Muslumanoglu (M)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Neslihan Cabioglu (N)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Abdullah Igci (A)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Hasan Karanlık (H)

Surgical Oncology Unit, Institute of Oncology, Istanbul University, Istanbul, Turkey.

Havva Belma Kocer (HB)

Department of General Surgery, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Kazim Senol (K)

Department of General Surgery, Uludag University Faculty of Medicine, Bursa, Turkey.

Baris Mantoglu (B)

Department of General Surgery, Sakarya University Training and Research Hospital, Sakarya, Turkey.

Mustafa Tukenmez (M)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Guldeniz Karadeniz Çakmak (GK)

Department of General Surgery, School of Medicine, Bulent Ecevit University, Zonguldak, Turkey.

Enver Ozkurt (E)

Department of General Surgery, İstanbul Florence Nightingale Hospital, Istanbul, Turkey.

Mehmet Ali Gulcelik (MA)

Department of Surgical Oncology, Gülhane Training and Research Hospital, Ankara, Turkey.

Selman Emiroglu (S)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Baran Mollavelioglu (B)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Nilufer Yildirim (N)

Department of Nuclear Medicine, Faculty of Medicine, Ankara Yildirim Beyazit University, Bilkent, Ankara, Turkey.

Suleyman Bademler (S)

Surgical Oncology Unit, Institute of Oncology, Istanbul University, Istanbul, Turkey.

Baha Zengel (B)

Department of General Surgery, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.

Didem Can Trabulus (DC)

Department of Surgery, Bahcesehir University, Istanbul, Turkey.

Mustafa Umit Ugurlu (MU)

Breast and Endocrine Surgery Unit, Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey.

Cihan Uras (C)

Department of Surgery, School of Medicine, Acibadem University, Istanbul, Turkey.

Serkan Ilgun (S)

Department of General Surgery, Demiroğlu Bilim University School of Medicine, Istanbul, Turkey.

Gokhan Giray Akgul (GG)

Department of Surgical Oncology, Gülhane Training and Research Hospital, Ankara, Turkey.

Alper Akcan (A)

Department of General Surgery, Faculty of Medicine, Erciyes University, Kayseri, Turkey.

Serdar Yormaz (S)

Department of General Surgery, Faculty of Medicine, Selçuk University, Konya, Turkey.

Yeliz Emine Ersoy (YE)

Department of General Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey.

Serdar Ozbas (S)

Department of Surgery, Ankara Guven Hospital, Ankara, Turkey.

Ece Dilege (E)

Department of General Surgery, Koç University School of Medicine, Istanbul, Turkey.

Bulent Citgez (B)

Department of General Surgery, Uskudar University Faculty of Medicine, Memorial Hospital, Istanbul, Turkey.

Yasemin Bolukbasi (Y)

Department of Radiation Oncology, Koç University Hospital, Istanbul, Turkey.

Ayse Altınok (A)

Department of Radiation Oncology, Medical Park Bahcelievler Hospital, Istanbul, Turkey.

Ahmet Dag (A)

Department of General Surgery, Medical Faculty, Mersin University, Mersin, Turkey.

Gül Basaran (G)

Department of Internal Medicine and Medical Oncology, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Nihat Zafer Utkan (NZ)

Department of General Surgery, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey.

Beyza Ozcinar (B)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Cumhur Arici (C)

Department of General Surgery, Akdeniz University School of Medicine, Antalya, Turkey.

Israa AlJorani (I)

Department of General Surgery, Uludag University Faculty of Medicine, Bursa, Turkey.

Halil Kara (H)

Department of Surgery, School of Medicine, Acibadem University, Istanbul, Turkey.

Banu Yigit (B)

Department of General Surgery, Sisli Hamidiye Etfal Medical Practice and Research Center, University of Health Sciences, Istanbul, Turkey.

Ebru Sen (E)

Clinic of General Surgery, Başakşehir Çam and Sakura City Hospital, University of Health Sciences Türkiye, Istanbul, Turkey.

Fazilet Erozgen (F)

General Surgery Clinic, Haseki Training and Research Hospital, Istanbul, Turkey.

Aykut Soyder (A)

Department of General Surgery, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Burak Celik (B)

Department of General Surgery, Koç University School of Medicine, Istanbul, Turkey.

Halime Gul Kilic (HG)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Leyla Zer (L)

Department of General Surgery, İstanbul Florence Nightingale Hospital, Istanbul, Turkey.

Gürhan Sakman (G)

Department of General Surgery, Cukurova University, Sarıcam, Adana, Turkey.

Levent Yeniay (L)

Department of General Surgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Kemal Atahan (K)

Department of General Surgery, Katip Çelebi University Atatürk Training and Research Hospital, Izmir, Turkey.

Ecenur Varol (E)

Department of General Surgery, Faculty of Medicine, University of Kocaeli, Kocaeli, Turkey.

Vefa Veliyeva (V)

Department of Surgical Oncology, Azerbaijan Medical University, Baku, Azerbaijan.

Berk Goktepe (B)

Department of General Surgery, Faculty of Medicine, Ege University, Izmir, Turkey.

Mehmet Velidedeoglu (M)

Department of General Surgery, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Niyazi Karaman (N)

Department of Surgical Oncology, Ankara Oncology Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Atilla Soran (A)

Department of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Adnan Aydiner (A)

Department of Medical Oncology, Institute of Oncology, Istanbul University, Istanbul, Turkey.

Ravza Yılmaz (R)

Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Kamuran Ibis (K)

Radiation Oncology Department, Oncology Institute, Istanbul University, Istanbul, Turkey.

Vahit Ozmen (V)

Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Classifications MeSH