Pharmacologic restoration of GTP hydrolysis by mutant RAS.

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
30 Oct 2024
Historique:
received: 23 04 2024
accepted: 24 10 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 30 10 2024
Statut: aheadofprint

Résumé

Approximately 3.4 million patients worldwide are diagnosed each year with cancers that harbor pathogenic mutations in one of three RAS proto-oncogenes (KRAS, NRAS and HRAS)

Identifiants

DOI: 10.1038/s41586-024-08283-2 PMID: 39476862
pubmed: 39476862
doi: 10.1038/s41586-024-08283-2
pii: 10.1038/s41586-024-08283-2
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

Auteurs

Antonio Cuevas-Navarro (A)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-6208-6944

Yasin Pourfarjam (Y)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0009-0009-8881-6824

Feng Hu (F)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0001-9605-7594

Diego J Rodriguez (DJ)

Tri-Institutional MD-PhD Program, Weill Cornell Medical College and Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, NY, USA.
ORCID: 0000-0002-0053-8674

Alberto Vides (A)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Ben Sang (B)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Shijie Fan (S)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Yehuda Goldgur (Y)

Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Elisa de Stanchina (E)

Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Piro Lito (P)

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.
Tri-Institutional MD-PhD Program, Weill Cornell Medical College and Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.
Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.
Department of Medicine, Weill Cornell Medical College, New York, NY, USA. litop@mskcc.org.
ORCID: 0000-0003-2196-3503

Classifications MeSH