Association of the triglyceride glucose index with myocardial ischemia in patients with minimal to moderate coronary artery disease.

Humans Male Female Coronary Artery Disease / blood Middle Aged Myocardial Ischemia / blood Triglycerides / blood Aged Retrospective Studies Blood Glucose / analysis Computed Tomography Angiography Coronary Angiography Insulin Resistance Fractional Flow Reserve, Myocardial Incidence
Computed tomography–derived fractional flow reserve Coronary artery disease Coronary computed tomography angiography Myocardial ischemia Triglyceride glucose index

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 10 2024
Historique:
received: 22 06 2024
accepted: 15 10 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 31 10 2024
Statut: epublish

Résumé

The triglyceride glucose (TyG) index has been suggested as a reliable substitute to indicate insulin resistance. Several studies have identified the association between the TyG index and cardiovascular disease. However, the association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate coronary artery disease (CAD) has not been clearly assessed. We aimed to investigate the association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate CAD. A total of 1,697 patients who underwent coronary computed tomography angiography (CTA) examinations and had minimal to moderate CAD were retrospectively included in the study. The TyG index and computed tomography-derived fractional flow reserve (CT-FFR) were used to assess insulin resistance (IR) and myocardial ischemia, respectively. Myocardial ischemia was defined as a CT-FFR value ≤ 0.80. Logistic regression models were used to explore the associations between the TyG index and myocardial ischemia. The incidence of myocardial ischemia was higher in the highest TyG index tertile (T3) group than in the lowest TyG index tertile (T1) group. After adjusting for other variables, the T3 group remained associated with a higher risk of myocardial ischemia than the T1 group did (OR, 1.43; 95% CI, 1.01-2.04; p = 0.047). A 1- standard deviation (SD) increase in the TyG index was correlated with a 19-24% elevated risk of myocardial ischemia when regarding the TyG index was considered as a continuous variable. Subgroup analysis revealed similar effects. A TyG index is associated with a higher risk of myocardial ischemia detected by CT-FFR in patients with minimal to moderate CAD.

Identifiants

DOI: 10.1038/s41598-024-76530-7 PMID: 39478011
pubmed: 39478011
doi: 10.1038/s41598-024-76530-7
pii: 10.1038/s41598-024-76530-7
doi:

Substances chimiques

Triglycerides 0
Blood Glucose 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26093

Subventions

Organisme : Health Commission of Wuhan Municipal Scientific Research Project
ID : WX23B17

Informations de copyright

© 2024. The Author(s).

Références

Cury, R. C. et al. CAD-RADS 2.0 - 2022 coronary artery disease-reporting and data system: An expert consensus document of the society of cardiovascular computed tomography (SCCT), the American College of Cardiology (ACC), the American College of Radiology (ACR), and the North America Society of Cardiovascular Imaging (NASCI). JACC Cardiovasc. Imaging 15, 1974–2001. https://doi.org/10.1016/j.jcmg.2022.07.002 (2022).
doi: 10.1016/j.jcmg.2022.07.002 pubmed: 36115815
Writing Committee, M. & AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J. Am. Coll. Cardiol. 78, 2218–2261. https://doi.org/10.1016/j.jacc.2021.07.052 (2021).
Arbab-Zadeh, A. & Fuster, V. From detecting the vulnerable plaque to managing the vulnerable patient: JACC state-of-the-art review. J. Am. Coll. Cardiol. 74, 1582–1593. https://doi.org/10.1016/j.jacc.2019.07.062 (2019).
doi: 10.1016/j.jacc.2019.07.062 pubmed: 31537269
Han, D. et al. Prognostic significance of plaque location in non-obstructive coronary artery disease: From the CONFIRM registry. Eur. Heart J. Cardiovasc. Imaging 23, 1240–1247. https://doi.org/10.1093/ehjci/jeab223 (2022).
doi: 10.1093/ehjci/jeab223 pubmed: 34791117
Leipsic, J. et al. Sex-based prognostic implications of nonobstructive coronary artery disease: Results from the international multicenter CONFIRM study. Radiology 273, 393–400. https://doi.org/10.1148/radiol.14140269 (2014).
doi: 10.1148/radiol.14140269 pubmed: 25028784
Emami, H. et al. Nonobstructive coronary artery disease by coronary CT angiography improves risk stratification and allocation of statin therapy. JACC Cardiovasc. Imaging 10, 1031–1038. https://doi.org/10.1016/j.jcmg.2016.10.022 (2017).
doi: 10.1016/j.jcmg.2016.10.022 pubmed: 28330658 pmcid: 6010207
Simental-Mendia, L. E., Rodriguez-Moran, M. & Guerrero-Romero, F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. Metab. Syndr. Relat. Disord. 6, 299–304. https://doi.org/10.1089/met.2008.0034 (2008).
doi: 10.1089/met.2008.0034 pubmed: 19067533
Kim, M. K. et al. Relationship between the triglyceride glucose index and coronary artery calcification in Korean adults. Cardiovasc. Diabetol. 16, 108. https://doi.org/10.1186/s12933-017-0589-4 (2017).
doi: 10.1186/s12933-017-0589-4 pubmed: 28830471 pmcid: 5568209
Sanchez-Inigo, L., Navarro-Gonzalez, D., Fernandez-Montero, A., Pastrana-Delgado, J. & Martinez, J. A. The TyG index may predict the development of cardiovascular events. Eur. J. Clin. Invest. 46, 189–197. https://doi.org/10.1111/eci.12583 (2016).
doi: 10.1111/eci.12583 pubmed: 26683265
Yuan, W., Shao, Y., Zhao, D. & Zhang, B. Correlation analysis of lipid accumulation index, triglyceride-glucose index and H-type hypertension and coronary artery disease. PeerJ. 11, e16069. https://doi.org/10.7717/peerj.16069 (2023).
doi: 10.7717/peerj.16069 pubmed: 37727694 pmcid: 10506588
Pan, W. et al. Triglyceride glucose index is associated with obstructive coronary artery disease in hypertensive patients. Cardiovasc. Diabetol. 22 https://doi.org/10.1186/s12933-023-01739-1 (2023).
Huang, Z. et al. Comparison of prognostic value between CAD-RADS 1.0 and CAD-RADS 2.0 evaluated by convolutional neural networks based CCTA. Heliyon 9, e15988. https://doi.org/10.1016/j.heliyon.2023.e15988 (2023).
doi: 10.1016/j.heliyon.2023.e15988 pubmed: 37215852 pmcid: 10195897
Huang, Z. et al. Clinical evaluation of the Automatic Coronary Artery Disease Reporting and Data System (CAD-RADS) in Coronary computed Tomography Angiography using Convolutional neural networks. Acad. Radiol. 30, 698–706. https://doi.org/10.1016/j.acra.2022.05.015 (2023).
doi: 10.1016/j.acra.2022.05.015 pubmed: 35753936
Dweck, M. R. & Newby, D. E. Non-obstructive coronary artery disease can no longer be ignored. Eur. Heart J. Cardiovasc. Imaging 21, 489–490. https://doi.org/10.1093/ehjci/jeaa022 (2020).
doi: 10.1093/ehjci/jeaa022 pubmed: 32068781
Douglas, P. S. et al. Outcomes of anatomical versus functional testing for coronary artery disease. N. Engl. J. Med. 372, 1291–1300. https://doi.org/10.1056/NEJMoa1415516 (2015).
doi: 10.1056/NEJMoa1415516 pubmed: 25773919 pmcid: 4473773
Investigators, S. H. et al. Coronary CT angiography and 5-Year risk of myocardial infarction. N. Engl. J. Med. 379, 924–933. https://doi.org/10.1056/NEJMoa1805971 (2018).
doi: 10.1056/NEJMoa1805971
Hoffmann, U. et al. Prognostic value of noninvasive cardiovascular testing in patients with stable chest pain: Insights from the PROMISE trial (prospective Multicenter Imaging Study for evaluation of chest Pain). Circulation. 135, 2320–2332. https://doi.org/10.1161/CIRCULATIONAHA.116.024360 (2017).
doi: 10.1161/CIRCULATIONAHA.116.024360 pubmed: 28389572 pmcid: 5946057
Min, J. K. et al. Rationale and design of the CONFIRM (COronary CT angiography EvaluatioN for clinical outcomes: An InteRnational Multicenter) Registry. J. Cardiovasc. Comput. Tomogr. 5, 84–92. https://doi.org/10.1016/j.jcct.2011.01.007 (2011).
doi: 10.1016/j.jcct.2011.01.007 pubmed: 21477786
van Rosendael, A. R. et al. Clinical risk factors and atherosclerotic plaque extent to define risk for major events in patients without obstructive coronary artery disease: The long-term coronary computed tomography angiography CONFIRM registry. Eur. Heart J. Cardiovasc. Imaging 21, 479–488. https://doi.org/10.1093/ehjci/jez322 (2020).
doi: 10.1093/ehjci/jez322 pubmed: 32065624 pmcid: 7821703
Maddox, T. M. et al. Nonobstructive coronary artery disease and risk of myocardial infarction. JAMA 312, 1754–1763. https://doi.org/10.1001/jama.2014.14681 (2014).
doi: 10.1001/jama.2014.14681 pubmed: 25369489 pmcid: 4893304
Hadamitzky, M. et al. Prognostic value of coronary computed tomography angiography during 5 years of follow-up in patients with suspected coronary artery disease. Eur. Heart J. 34, 3277–3285. https://doi.org/10.1093/eurheartj/eht293 (2013).
doi: 10.1093/eurheartj/eht293 pubmed: 24067508
Ihdayhid, A. R. et al. Prognostic value and risk continuum of noninvasive fractional flow reserve derived from coronary CT angiography. Radiology 292, 343–351. https://doi.org/10.1148/radiol.2019182264 (2019).
doi: 10.1148/radiol.2019182264 pubmed: 31184558
Zhao, N. et al. CT-FFR vs a model of combined plaque characteristics for identifying ischemia: Results from CT-FFR CHINA trial. Eur. J. Radiol. 138, 109634. https://doi.org/10.1016/j.ejrad.2021.109634 (2021).
doi: 10.1016/j.ejrad.2021.109634 pubmed: 33721765
Solymoss, B. C. et al. Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease. Coron. Artery Dis. 14, 207–212. https://doi.org/10.1097/01.mca.0000065744.52558.9f (2003).
doi: 10.1097/01.mca.0000065744.52558.9f pubmed: 12702923
Solymoss, B. C. et al. Effect of increasing metabolic syndrome score on atherosclerotic risk profile and coronary artery disease angiographic severity. Am. J. Cardiol. 93, 159–164. https://doi.org/10.1016/j.amjcard.2003.09.032 (2004).
doi: 10.1016/j.amjcard.2003.09.032 pubmed: 14715340
Norgaard, B. L. et al. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: The NXT trial (analysis of Coronary Blood Flow using CT angiography: next steps). J. Am. Coll. Cardiol. 63, 1145–1155. https://doi.org/10.1016/j.jacc.2013.11.043 (2014).
doi: 10.1016/j.jacc.2013.11.043 pubmed: 24486266
Yu, B. et al. Triglyceride-glucose index is associated with quantitative flow ratio in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention. Front. Cardiovasc. Med. 9, 1002030. https://doi.org/10.3389/fcvm.2022.1002030 (2022).
doi: 10.3389/fcvm.2022.1002030 pubmed: 36158820 pmcid: 9493184
Schulman, I. H. & Zhou, M. S. Vascular insulin resistance: A potential link between cardiovascular and metabolic diseases. Curr. Hypertens. Rep. 11, 48–55. https://doi.org/10.1007/s11906-009-0010-0 (2009).
doi: 10.1007/s11906-009-0010-0 pubmed: 19146801
Lee, E. Y. et al. Triglyceride glucose index, a marker of insulin resistance, is associated with coronary artery stenosis in asymptomatic subjects with type 2 diabetes. Lipids Health Dis. 15 https://doi.org/10.1186/s12944-016-0324-2 (2016).
Wang, J., Huang, X., Fu, C., Sheng, Q. & Liu, P. Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome. Cardiovasc. Diabetol. 21, 187. https://doi.org/10.1186/s12933-022-01615-4 (2022).
doi: 10.1186/s12933-022-01615-4 pubmed: 36114495 pmcid: 9482257
Su, J. et al. Triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with coronary heart disease: A RCSCD-TCM study in China. Cardiovasc. Diabetol. 21, 96. https://doi.org/10.1186/s12933-022-01523-7 (2022).
doi: 10.1186/s12933-022-01523-7 pubmed: 35668496 pmcid: 9169264
Zhao, J. et al. TyG index is positively associated with risk of CHD and coronary atherosclerosis severity among NAFLD patients. Cardiovasc. Diabetol. 21, 123. https://doi.org/10.1186/s12933-022-01548-y (2022).
doi: 10.1186/s12933-022-01548-y pubmed: 35778734 pmcid: 9250269
Wang, W. et al. Association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute coronary syndrome: Results from the improving care for Cardiovascular Disease in China (CCC)-Acute Coronary Syndrome project. Cardiovasc. Diabetol. 23, 170. https://doi.org/10.1186/s12933-024-02270-7 (2024).
doi: 10.1186/s12933-024-02270-7 pubmed: 38750553 pmcid: 11097581
Rokicka, D. et al. The prognostic impact of insulin resistance surrogates in patients with acute myocardial infarction with and without type 2 diabetes. Cardiovasc. Diabetol. 23, 147. https://doi.org/10.1186/s12933-024-02240-z (2024).
doi: 10.1186/s12933-024-02240-z pubmed: 38685054 pmcid: 11059609
Ye, Z. et al. Predicting long-term prognosis after percutaneous coronary intervention in patients with new onset ST-elevation myocardial infarction: Development and external validation of a nomogram model. Cardiovasc. Diabetol. 22, 87. https://doi.org/10.1186/s12933-023-01820-9 (2023).
doi: 10.1186/s12933-023-01820-9 pubmed: 37055777 pmcid: 10103457
Zhao, X. et al. Triglyceride glucose index combined with plaque characteristics as a novel biomarker for cardiovascular outcomes after percutaneous coronary intervention in ST-elevated myocardial infarction patients: An intravascular optical coherence tomography study. Cardiovasc. Diabetol. 20, 131. https://doi.org/10.1186/s12933-021-01321-7 (2021).
doi: 10.1186/s12933-021-01321-7 pubmed: 34183007 pmcid: 8240222
Santulli, G. et al. Prediabetes increases the risk of Frailty in Prefrail older adults with hypertension: Beneficial effects of Metformin. Hypertension 81, 1637–1643. https://doi.org/10.1161/HYPERTENSIONAHA.124.23087 (2024).
doi: 10.1161/HYPERTENSIONAHA.124.23087 pubmed: 38752357

Auteurs

Zengfa Huang (Z)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China. hzfz88@163.com.

Ruiyao Tang (R)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.

Yi Ding (Y)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.

Wanpeng Wang (W)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.

Xinyu Du (X)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.
Department of Radiology, The Central Hospital of Wuhan Base, Hubei University of Medicine, Shiyan, 442000, Hubei, China.

Xi Wang (X)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.

Zuoqin Li (Z)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.

Jianwei Xiao (J)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China.

Xiang Wang (X)

Department of Radiology, Tongji Medical College, The Central Hospital of Wuhan, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, 430014, Hubei, China. wangxiangwhch1971@163.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of the triglyceride glucose index...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Maladie coronarienne › Maladie des artères coronaires › Association of the triglyceride glucose index...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Association of the triglyceride glucose index...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Ischémie myocardique › Association of the triglyceride glucose index...
questionsmedicales.fr › Lipides › Glycérides › Triglycéride › Association of the triglyceride glucose index...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of the triglyceride glucose index...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Association of the triglyceride glucose index...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › Association of the triglyceride glucose index...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Angiographie par tomodensitométrie › Association of the triglyceride glucose index...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Tests de la fonction cardiaque › Coronarographie › Association of the triglyceride glucose index...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Association of the triglyceride glucose index...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Circulation coronarienne › Fraction du flux de réserve coronaire › Association of the triglyceride glucose index...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Incidence › Association of the triglyceride glucose index...