Withaferin a modulation of microglia autophagy mitigates neuroinflammation and enhances cognitive function in POCD.
Withanolides
/ pharmacology
Animals
Microglia
/ drug effects
Autophagy
/ drug effects
Mice
Neuroinflammatory Diseases
/ drug therapy
Cognition
/ drug effects
Postoperative Cognitive Complications
/ drug therapy
Male
Hippocampus
/ drug effects
Disease Models, Animal
Mice, Inbred C57BL
Withania
/ chemistry
Inflammation
/ drug therapy
Interleukin-1beta
/ metabolism
LDs
Neuroinflammation
POCD
Withaferin A
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 10 2024
30 10 2024
Historique:
received:
20
05
2024
accepted:
03
10
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
With the aging process of the global population and the development of medical technology, the cases of postoperative cognitive dysfunction (POCD) are also increasing. Due to the complexity of the pathogenesis, urgent treatment has been sought. Neuroinflammation induced by the accumulation of lipid droplets (LDs) in microglia has been closely watched in recent years and is also considered to be an important cause of nerve damage. Our study found that derived from Withania somnifera, Withaferin A (WA) could reduce the accumulation of LDs in the hippocampus of POCD mice, inhibit the expression of inflammatory factor interleukin-1β (IL-1β), and improve the cognitive ability of mice. Further in vitro experimental studies showed that WA increased the autophagy level of microglia, promoted the degradation of LDs, and reduced the production of inflammatory factors. In this regard, our comprehensive research endeavor holds the potential to furnish novel insights into therapeutic strategies aimed at addressing POCD and its associated neural impairments.
Identifiants
pubmed: 39478022
doi: 10.1038/s41598-024-75284-6
pii: 10.1038/s41598-024-75284-6
doi:
Substances chimiques
withaferin A
L6DO3QW4K5
Withanolides
0
Interleukin-1beta
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26112Subventions
Organisme : National Natural Science Foundation of China
ID : 82360227
Organisme : Natural Science Foundation of Jiangxi Province
ID : 20232BAB206060
Informations de copyright
© 2024. The Author(s).
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