Adverse effects of CXCR2 deficiency in mice reared under non-gnotobiotic conditions.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 10 2024
30 10 2024
Historique:
received:
22
01
2024
accepted:
07
10
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
The family of pro-inflammatory and pro-angiogenic chemokines including Interleukin-8 (IL-8, aka CXCL8) and its homologues (CXCL1,2,3,5,6, and 7) exhibit promiscuous binding and activation of several G-protein-coupled receptors (i.e., CXCR2, CXCR1, and the atypical chemokine receptor (ACKR1)). A high proportion of their biological activity is attributed to CXCR2 activation, thus many CXCR2 inhibitors are in clinical trials for several chronic diseases. However, CXCR2 inhibition is often only investigated acutely in these trials or in Cxcr2
Identifiants
pubmed: 39478033
doi: 10.1038/s41598-024-75532-9
pii: 10.1038/s41598-024-75532-9
doi:
Substances chimiques
Receptors, Interleukin-8B
0
Cxcr2 protein, mouse
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
26159Subventions
Organisme : International Retinal Research Foundation
ID : GF02527
Organisme : NEI NIH HHS
ID : K08 EY029006
Pays : United States
Organisme : Vanderbilt Diabetes Research and Training Center, Vanderbilt University Medical Center
ID : DK020593
Organisme : Research to Prevent Blindness
ID : Unrestricted Grant
Informations de copyright
© 2024. The Author(s).
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