A cross-systems primer for synthetic microbial communities.
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
Nov 2024
Nov 2024
Historique:
received:
02
02
2024
accepted:
11
09
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
ppublish
Résumé
The design and use of synthetic communities, or SynComs, is one of the most promising strategies for disentangling the complex interactions within microbial communities, and between these communities and their hosts. Compared to natural communities, these simplified consortia provide the opportunity to study ecological interactions at tractable scales, as well as facilitating reproducibility and fostering interdisciplinary science. However, the effective implementation of the SynCom approach requires several important considerations regarding the development and application of these model systems. There are also emerging ethical considerations when both designing and deploying SynComs in clinical, agricultural or environmental settings. Here we outline current best practices in developing, implementing and evaluating SynComs across different systems, including a focus on important ethical considerations for SynCom research.
Identifiants
pubmed: 39478083
doi: 10.1038/s41564-024-01827-2
pii: 10.1038/s41564-024-01827-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2765-2773Subventions
Organisme : NSF | BIO | Division of Integrative Organismal Systems (IOS)
ID : 1838299
Organisme : National Science Foundation (NSF)
ID : DBI-2209151
Informations de copyright
© 2024. Springer Nature Limited.
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