A cross-systems primer for synthetic microbial communities.


Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
Nov 2024
Historique:
received: 02 02 2024
accepted: 11 09 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 31 10 2024
Statut: ppublish

Résumé

The design and use of synthetic communities, or SynComs, is one of the most promising strategies for disentangling the complex interactions within microbial communities, and between these communities and their hosts. Compared to natural communities, these simplified consortia provide the opportunity to study ecological interactions at tractable scales, as well as facilitating reproducibility and fostering interdisciplinary science. However, the effective implementation of the SynCom approach requires several important considerations regarding the development and application of these model systems. There are also emerging ethical considerations when both designing and deploying SynComs in clinical, agricultural or environmental settings. Here we outline current best practices in developing, implementing and evaluating SynComs across different systems, including a focus on important ethical considerations for SynCom research.

Identifiants

pubmed: 39478083
doi: 10.1038/s41564-024-01827-2
pii: 10.1038/s41564-024-01827-2
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2765-2773

Subventions

Organisme : NSF | BIO | Division of Integrative Organismal Systems (IOS)
ID : 1838299
Organisme : National Science Foundation (NSF)
ID : DBI-2209151

Informations de copyright

© 2024. Springer Nature Limited.

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Auteurs

Elijah C Mehlferber (EC)

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA. emehlferber@berkeley.edu.
Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, GA, USA. emehlferber@berkeley.edu.

Gontran Arnault (G)

Univ Angers, Institut Agro, INRAE, IRHS, SFR QUASAV, Angers, France.

Bishnu Joshi (B)

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.

Laila P Partida-Martinez (LP)

Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (Cinvestav), Irapuato, México.

Kathryn A Patras (KA)

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USA.
Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, USA.

Marie Simonin (M)

Univ Angers, Institut Agro, INRAE, IRHS, SFR QUASAV, Angers, France.

Britt Koskella (B)

Department of Integrative Biology, University of California, Berkeley, CA, USA. bkoskella@berkeley.edu.
San Francisco Chan Zuckerberg Biohub, San Francisco, CA, USA. bkoskella@berkeley.edu.

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