Liver magnetic resonance imaging, non-alcoholic fatty liver disease and metabolic syndrome risk in pre-pubertal Mexican boys.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 10 2024
Historique:
received: 06 03 2024
accepted: 21 10 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 31 10 2024
Statut: epublish

Résumé

Rising global pediatric obesity rates, increase non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) prevalence, with MetS being a NAFLD risk factor. NAFLD can be asymptomatic, with liver function tests insensitive to mild disease, and liver biopsy, risking complications. Thus, we investigated multiparametric MRI (mpMRI) metrics of liver fat (proton density fat fraction, PDFF) and disease activity (fibro-inflammation; iron-corrected T1, cT1), in a Hispanic pre-pubertal pediatric cohort, with increased risk of NAFLD. Pre-pubertal boys (n = 81) of varying Body-Mass Index (BMI) were recruited in Mexico City. Most children (81%) had normal liver transaminase levels, 38% had high BMI, and 14% had ≥ 3 MetS risk factors. Applying mpMRI thresholds, 12%, 7% and 4% of the cohort had NAFLD, NASH and high-risk NASH respectively. Participants with ≥ 3 MetS risk factors had higher cT1 (834 ms vs. 737 ms, p = 0.004) and PDFF (8.7% vs. 2.2%, p < 0.001) compared to those without risk factors. Those with elevated cT1 tended to have high BMI and high insulin (p = 0.005), HOMA-IR (p = 0.005) and leptin (p < 0.001). The significant association of increased risk of MetS with abnormal mpMRI, particularly cT1, proposes the potential of using mpMRI for routine pediatric NAFLD screening of high-risk (high BMI, high MetS risk score) populations.

Identifiants

pubmed: 39478096
doi: 10.1038/s41598-024-77307-8
pii: 10.1038/s41598-024-77307-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26104

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Benito de Celis Alonso (B)

Faculty of Physical and Mathematical Sciences, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.

Elizabeth Shumbayawonda (E)

Perspectum Ltd., Oxford, UK.

Cayden Beyer (C)

Perspectum Ltd., Oxford, UK.

Silvia Hidalgo-Tobon (S)

Imaging Department, Children's Hospital of Mexico Federico Gómez, Mexico City, Mexico.
Physics Department, UAM Iztapalapa, Mexico City, Mexico.

Briseida López-Martínez (B)

Research Direction/Coordination, Hospital Juarez of Mexico, Mexico City, Mexico.

Pilar Dies-Suarez (P)

Imaging Department, Children's Hospital of Mexico Federico Gómez, Mexico City, Mexico.

Miguel Klunder-Klunder (M)

Epidemiological Research Unit in Endocrinology and Nutrition, Children's Hospital of Mexico Federico Gomez, Mexico City, Mexico.

América Liliana Miranda-Lora (AL)

Epidemiological Research Unit in Endocrinology and Nutrition, Children's Hospital of Mexico Federico Gomez, Mexico City, Mexico.

Eduardo Barragán Pérez (EB)

Neurology Department, Children's Hospital of Mexico Federico Gomez, Mexico City, Mexico.

Helena Thomaides-Brears (H)

Perspectum Ltd., Oxford, UK.

Rajarshi Banerjee (R)

Perspectum Ltd., Oxford, UK.

E Louise Thomas (EL)

Research Centre for Optimal Health, University of Westminster, London, UK.

Jimmy D Bell (JD)

Research Centre for Optimal Health, University of Westminster, London, UK.

Po-Wah So (PW)

Department of Neuroimaging, King's College London, London, UK. po-wah.so@kcl.ac.uk.

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