Early pulmonary fibrosis-like changes between delta and pre-delta periods in patients with severe COVID-19 pneumonia on mechanical ventilation.

Humans COVID-19 / pathology Male Female Middle Aged Respiration, Artificial Aged Pulmonary Fibrosis / diagnostic imaging Tomography, X-Ray Computed SARS-CoV-2 / isolation & purification Republic of Korea / epidemiology Lung / diagnostic imaging Critical Illness
Mechanical ventilation Pulmonary fibrosis-like change SARS-CoV-2

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 10 2024
Historique:
received: 13 02 2024
accepted: 22 10 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 31 10 2024
Statut: epublish

Résumé

It remains unclear whether pulmonary fibrosis-like changes differ in patients with different SARS-CoV-2 variants. This study aimed to compare pulmonary fibrotic changes between two SARS-CoV-2 variant periods (delta vs. pre-delta) in critically ill patients with SARS-CoV-2 pneumonia. Clinical data and chest CT images of patients with SARS-CoV-2 pneumonia receiving mechanical ventilation were collected from 10 hospitals in South Korea over two periods: delta (July-December, 2021; n = 64) and pre-delta (February, 2020-June, 2021; n = 120). Fibrotic changes on chest CT were evaluated through visual assessment. Of 184 patients, the mean age was 64.6 years, and 60.5% were ale. Fibrosis-like changes on chest CT (median 51 days from enrollment to follow up CT scan, interquartile range 27-76 days) were identified in 75.3%. Delta group showed more fibrosis-like changes (≥ 2) (69.8% vs. 43.1%, P = 0.001) and more frequent reticulation and architectural distortion+/-parenchymal band than pre-delta group. Even after propensity score matching with clinical variables, delta group had more severe (≥ 2) fibrosis-like changes (71.4% vs. 38.8%, P = 0.001), and more frequent reticulation and architectural distortion+/-parenchymal band than pre-delta group. Our data suggest that critically ill patients with SARS-CoV-2 in delta period had more severe pulmonary fibrosis-like changes than those in pre-delta period.

Identifiants

DOI: 10.1038/s41598-024-77405-7 PMID: 39478105
pubmed: 39478105
doi: 10.1038/s41598-024-77405-7
pii: 10.1038/s41598-024-77405-7
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

26101

Subventions

Organisme : the Basic Science Research Program and the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science & ICT
ID : NRF-2022R1A2B5B02001602 and NRF-2022M3A9E4082647
Organisme : the National Institute of Health research project and Korea Environment Industry & Technology Institute through Core Technology Development Project for Environmental Diseases Prevention and Management Program funded by Korea Ministry of Environment
ID : 2021ER190400, 2021ER120701 and RS-2022-KE002197

Informations de copyright

© 2024. The Author(s).

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Auteurs

Jung-Wan Yoo (JW)

Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea.

Won-Young Kim (WY)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chung Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Chi Ryang Chung (CR)

Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.

Young-Jae Cho (YJ)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Jinwoo Lee (J)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Yangjin Jegal (Y)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Junghyun Kim (J)

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea.

Joon-Sung Joh (JS)

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Republic of Korea.

Tae Yun Park (TY)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

Ae-Rin Baek (AR)

Division of Allergy and Pulmonology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Joo Hun Park (JH)

Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.

Ganghee Chae (G)

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Republic of Korea.

Jung Hwa Hwang (JH)

Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea.

Jin Woo Song (JW)

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-Gu 05505, Seoul, Republic of Korea. jwsongasan@gmail.com.

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questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Early pulmonary fibrosis-like changes between...
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questionsmedicales.fr › Thérapeutique › Thérapie respiratoire › Ventilation artificielle › Early pulmonary fibrosis-like changes between...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Early pulmonary fibrosis-like changes between...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Fibrose pulmonaire › Early pulmonary fibrosis-like changes between...
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