Fibrolytic vaccination against ADAM12 reduces desmoplasia in preclinical pancreatic adenocarcinomas.
Cancer-Associated Fibroblasts
Immunotherapy
Pancreatic Adenocarcinoma
Vaccination
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: Germany
ID NLM: 101487380
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
20
10
2023
accepted:
09
10
2024
revised:
26
09
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
aheadofprint
Résumé
A hallmark feature of pancreatic ductal adenocarcinoma (PDAC) is massive intratumoral fibrosis, designated as desmoplasia. Desmoplasia is characterized by the expansion of cancer-associated fibroblasts (CAFs) and a massive increase in extracellular matrix (ECM). During fibrogenesis, distinct genes become reactivated specifically in fibroblasts, e.g., the disintegrin metalloprotease, ADAM12. Previous studies have shown that immunotherapeutic ablation of ADAM12
Identifiants
pubmed: 39478152
doi: 10.1038/s44321-024-00157-4
pii: 10.1038/s44321-024-00157-4
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : SNF | Swiss National Centre of Competence in Research Kidney Control of Homeostasis (NCCR Kidney.CH)
ID : N-403-06-26 HCP
Organisme : Swiss Cancer League
ID : KFS-4398-02-2018
Organisme : Swiss Cancer League
ID : KFS-5402-08-2021
Organisme : Swiss National Science Fundation
ID : 310030_179235
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP23gm6510023
Organisme : University of Zurich
ID : Forschungskredit UZH Postdoc 2019
Informations de copyright
© 2024. The Author(s).
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