RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax.


Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
30 Oct 2024
Historique:
received: 26 07 2023
accepted: 30 09 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 31 10 2024
Statut: aheadofprint

Résumé

Cancer driver mutations often show distinct temporal acquisition patterns, but the biological basis for this, if any, remains unknown. RAS mutations occur invariably late in the course of acute myeloid leukaemia, upon progression or relapsed/refractory disease

Identifiants

pubmed: 39478230
doi: 10.1038/s41586-024-08137-x
pii: 10.1038/s41586-024-08137-x
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

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Auteurs

Junya Sango (J)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Saul Carcamo (S)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Maria Sirenko (M)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Abhishek Maiti (A)

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Hager Mansour (H)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Gulay Ulukaya (G)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Lewis E Tomalin (LE)

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Nataly Cruz-Rodriguez (N)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Tiansu Wang (T)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Malgorzata Olszewska (M)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Emmanuel Olivier (E)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Manon Jaud (M)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bettina Nadorp (B)

Department of Medicine, Division of Precision Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Department of Pathology, NYU Grossman School of Medicine, New York, NY, USA.

Benjamin Kroger (B)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Feng Hu (F)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Lewis Silverman (L)

Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Stephen S Chung (SS)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Elvin Wagenblast (E)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Ronan Chaligne (R)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.

Ann-Kathrin Eisfeld (AK)

Clara D. Bloomfield Center for Leukemia Outcomes Research, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.

Deniz Demircioglu (D)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Dan A Landau (DA)

Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.
New York Genome Center, New York, NY, USA.

Piro Lito (P)

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Elli Papaemmanuil (E)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Courtney D DiNardo (CD)

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Dan Hasson (D)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bioinformatics for Next Generation Sequencing Shared Resource Facility, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Marina Konopleva (M)

Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, NY, USA.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
Montefiore Einstein Comprehensive Cancer Center, Bronx, NY, USA.

Eirini P Papapetrou (EP)

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.
Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.
Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.
Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.
Center for Advancement of Blood Cancer Therapies, Icahn School of Medicine at Mount Sinai, New York, NY, USA. eirini.papapetrou@mssm.edu.

Classifications MeSH