MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.
Humans
Male
Infertility, Male
/ genetics
Methylenetetrahydrofolate Reductase (NADPH2)
/ genetics
Genetic Predisposition to Disease
/ genetics
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
/ genetics
Ferredoxin-NADP Reductase
/ genetics
Polymorphism, Single Nucleotide
Case-Control Studies
Risk Factors
Folate-metabolizing gene
MTHFR A1298C
MTHFR C677T
MTR A2756G
MTRR A66G
Male infertility
Journal
Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627
Informations de publication
Date de publication:
30 Oct 2024
30 Oct 2024
Historique:
received:
21
06
2023
accepted:
23
10
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
Epidemiological studies have reported that polymorphisms of folate-metabolizing genes have a significant impact on male infertility. However, the results of published studies have come to different conclusions. To determine an association between folate-metabolizing gene polymorphisms and the risk of male infertility. The meta-analysis was conducted according to the PRISMA 2020 statement. The protocol was registered with PROSPERO (CRD42023412251). Studies were searched from PubMed, Google Scholar, Embase, Scopus, and the Cochrane Library up to 24st October2023. Articles that satisfied the inclusion criteria were evaluated for their quality using the Newcastle-Ottawa Scale. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Meta-analysis was conducted using STATA 12. Forty-six case-control studies were included in the meta-analysis which comprised 20,639 participants. The pooled analysis revealed that the MTHFR C677T polymorphism was significantly associated with male infertility and abnormospermia.Three-fifths of the model showed there was a significant association between the MTR A2756G polymorphism and male infertility. Both MTHFR A1298C and MTRR A66G polymorphisms were not significantly associated with male fertility. Furthermore, subgroup analysis revealed a significant association between the MTHFR C677T polymorphism and male fertility in Asian countries. This meta-analysis suggests that the MTHFR C677T and MTR A2756G polymorphisms may be a potential risk factor for male infertility.
Sections du résumé
BACKGROUND
BACKGROUND
Epidemiological studies have reported that polymorphisms of folate-metabolizing genes have a significant impact on male infertility. However, the results of published studies have come to different conclusions.
OBJECTIVE
OBJECTIVE
To determine an association between folate-metabolizing gene polymorphisms and the risk of male infertility.
METHODS
METHODS
The meta-analysis was conducted according to the PRISMA 2020 statement. The protocol was registered with PROSPERO (CRD42023412251). Studies were searched from PubMed, Google Scholar, Embase, Scopus, and the Cochrane Library up to 24st October2023. Articles that satisfied the inclusion criteria were evaluated for their quality using the Newcastle-Ottawa Scale. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Meta-analysis was conducted using STATA 12.
RESULTS
RESULTS
Forty-six case-control studies were included in the meta-analysis which comprised 20,639 participants. The pooled analysis revealed that the MTHFR C677T polymorphism was significantly associated with male infertility and abnormospermia.Three-fifths of the model showed there was a significant association between the MTR A2756G polymorphism and male infertility. Both MTHFR A1298C and MTRR A66G polymorphisms were not significantly associated with male fertility. Furthermore, subgroup analysis revealed a significant association between the MTHFR C677T polymorphism and male fertility in Asian countries.
CONCLUSION
CONCLUSIONS
This meta-analysis suggests that the MTHFR C677T and MTR A2756G polymorphisms may be a potential risk factor for male infertility.
Identifiants
pubmed: 39478547
doi: 10.1186/s12958-024-01306-7
pii: 10.1186/s12958-024-01306-7
doi:
Substances chimiques
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
MTHFR protein, human
EC 1.5.1.20
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
EC 2.1.1.13
methionine synthase reductase
EC 1.18.1.-
Ferredoxin-NADP Reductase
EC 1.18.1.2
MTR protein, human
EC 2.1.1.13.
Types de publication
Systematic Review
Meta-Analysis
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
133Informations de copyright
© 2024. The Author(s).
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