A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex.

Phospholipase C gamma / metabolism Animals Signal Transduction Receptors, Antigen, T-Cell / metabolism Adaptor Proteins, Signal Transducing / metabolism Mice Phosphotransferases (Alcohol Group Acceptor) / metabolism Mice, Inbred C57BL Humans Protein Binding Mice, Knockout Concanavalin A / pharmacology
Hepatitis Inositol polyphosphate multikinase Phospholipase C gamma 1 Sam68 T cell receptor

Journal

Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464

Informations de publication

Date de publication:
30 Oct 2024
Historique:
received: 26 04 2024
accepted: 22 10 2024
medline: 31 10 2024
pubmed: 31 10 2024
entrez: 31 10 2024
Statut: epublish

Résumé

Phospholipase C gamma 1 (PLCγ1) is an important mediator of the T cell receptor (TCR) and growth factor signaling. PLCγ1 is activated by Src family kinases (SFKs) and produces inositol 1,4,5-triphosphate (InsP Concanavalin A (ConA)-induced acute hepatitis model was established in CD4 IPMK Our results demonstrate that IPMK non-catalytically promotes PLCγ1 phosphorylation by stabilizing the PLCγ1-Sam68 complex. Targeting IPMK in CD4

Sections du résumé

BACKGROUND BACKGROUND
Phospholipase C gamma 1 (PLCγ1) is an important mediator of the T cell receptor (TCR) and growth factor signaling. PLCγ1 is activated by Src family kinases (SFKs) and produces inositol 1,4,5-triphosphate (InsP
METHODS METHODS
Concanavalin A (ConA)-induced acute hepatitis model was established in CD4
RESULTS RESULTS
IPMK
CONCLUSIONS CONCLUSIONS
Our results demonstrate that IPMK non-catalytically promotes PLCγ1 phosphorylation by stabilizing the PLCγ1-Sam68 complex. Targeting IPMK in CD4

Identifiants

DOI: 10.1186/s12964-024-01907-0 PMID: 39478550
pubmed: 39478550
doi: 10.1186/s12964-024-01907-0
pii: 10.1186/s12964-024-01907-0
doi:

Substances chimiques

Phospholipase C gamma EC 3.1.4.3
Receptors, Antigen, T-Cell 0
Adaptor Proteins, Signal Transducing 0
inositol polyphosphate multikinase EC 2.7.1.-
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
Sh2d2a protein, mouse 0
Concanavalin A 11028-71-0
Plcg1 protein, mouse EC 3.1.4.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

526

Subventions

Organisme : National Research Foundation of Korea
ID : NRF-2018R1A5A1024261

Informations de copyright

© 2024. The Author(s).

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Auteurs

Sehoon Hong (S)

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Kyurae Kim (K)

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Young-Ri Shim (YR)

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Jiyeon Park (J)

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Sung Eun Choi (SE)

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Hyungyu Min (H)

School of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.

Seulgi Lee (S)

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Ji-Joon Song (JJ)

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Suk-Jo Kang (SJ)

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Won-Il Jeong (WI)

Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea.

Rho Hyun Seong (RH)

School of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul, 08826, Republic of Korea.

Seyun Kim (S)

Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Youseong-Gu, Daejeon, 34141, Republic of Korea. seyunkim@kaist.ac.kr.
KAIST Institute for the BioCentury, KAIST, Daejeon, 34141, Republic of Korea. seyunkim@kaist.ac.kr.
KAIST Stem Cell Center, KAIST, Daejeon, 34141, Republic of Korea. seyunkim@kaist.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphoinositide Phospholipase C › Phospholipase C gamma › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Eucaryotes › Animaux › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › A non-catalytic role of IPMK is required for...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines végétales › Lectines végétales › Concanavaline A › A non-catalytic role of IPMK is required for...