Incidence, prevalence and clinical presentation of inflammatory bowel diseases in Northern France: a 30-year population-based study.
Crohn’s disease
Incidence
Inflammatory bowel disease
Population-based registry
Prevalence
Ulcerative colitis
Journal
The Lancet regional health. Europe
ISSN: 2666-7762
Titre abrégé: Lancet Reg Health Eur
Pays: England
ID NLM: 101777707
Informations de publication
Date de publication:
Dec 2024
Dec 2024
Historique:
received:
31
07
2024
revised:
27
09
2024
accepted:
30
09
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
epublish
Résumé
In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period. Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time. A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn's disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 10 The persistent increase of IBD incidence among children and young adults but also in women with UC in Northern France, suggests the persistence of substantial predisposing environmental factors. Santé Publique France; INSERM; Amiens, Lille and Rouen University Hospitals.
Sections du résumé
Background
UNASSIGNED
In industrialized countries, the incidence of inflammatory bowel disease (IBD) appears stabilized. This study examined the incidence and phenotype of IBD in Northern France over a 30-year period.
Methods
UNASSIGNED
Including all IBD patients recorded in the EPIMAD population-based registry from 1988 to 2017 in Northern France, we described the incidence and clinical presentation of IBD according to age, sex and time.
Findings
UNASSIGNED
A total of 22,879 incident IBD cases were documented (59% (n = 13,445) of Crohn's disease (CD), 38% (n = 8803) of ulcerative colitis (UC), 3% (n = 631) of IBD unclassified (IBDU)). Over the study period, incidence of IBD, CD and UC was 12.7, 7.2 and 5.1 per 10
Interpretation
UNASSIGNED
The persistent increase of IBD incidence among children and young adults but also in women with UC in Northern France, suggests the persistence of substantial predisposing environmental factors.
Funding
UNASSIGNED
Santé Publique France; INSERM; Amiens, Lille and Rouen University Hospitals.
Identifiants
pubmed: 39478988
doi: 10.1016/j.lanepe.2024.101097
pii: S2666-7762(24)00264-3
pmc: PMC11522416
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101097Investigateurs
Eric Agoute
(E)
Najib Al Ghossaini
(N)
Raied Al Hameedi
(R)
Myriam Al Khatib
(M)
Saria Al Turk
(S)
Jean-Marie Andre
(JM)
Matthieu Antoine
(M)
Michel Antonietti
(M)
Amar Aouakli
(A)
Laura Armengol-Debeir
(L)
Ibrahim Aroichane
(I)
Fadi Assi
(F)
Eric Auxenfants
(E)
Alina Avram
(A)
Kassem Azzouzi
(K)
Damyan Bankovski
(D)
Bernard Barbry
(B)
Nicolas Bardoux
(N)
Philippe Baron
(P)
Anne Baudet
(A)
Pauline Bayart
(P)
Brice Bazin
(B)
Arash Bebahani
(A)
Jean-Pierre Becqwort
(JP)
Houssem Ben Ali
(H)
Emmanuel Ben Soussan
(E)
Coralie Benard
(C)
Vincent Benet
(V)
Corinne Benguigui
(C)
Abdeslam Bental
(A)
Sara Bentaleb-Bellati
(S)
Isabelle Berkelmans
(I)
Jacques Bernet
(J)
Karine Bernou
(K)
Nathalie Bertiaux-Vandaele
(N)
Pauline Bertot
(P)
Valérie Bertrand
(V)
Emilie Biloud
(E)
Nathalie Biron
(N)
Benjamin Bismuth
(B)
Cyril Blanchard
(C)
Maurice Bleuez
(M)
Fabienne Blondel
(F)
Valérie Blondin
(V)
Marius Bobula
(M)
Philippe Bohont
(P)
Eléonore Boivin
(E)
Vanessa Bon Djemah
(VB)
Eric Boniface
(E)
Philippe Bonniere
(P)
Pierre Bonvarlet
(P)
Arnaud Boruchowicz
(A)
Raoul Bostvironnois
(R)
Médina Boualit
(M)
Ahlem Bouazza
(A)
Bruno Bouche
(B)
Christian Boudailler
(C)
Claude Bourgeaux
(C)
Morgane Bourgeois-Fumery
(M)
Arnaud Bourguet
(A)
Agnès Bourienne
(A)
Hamza Boutaleb
(H)
Alexis Bouthors
(A)
Julien Branche
(J)
Franck Brazier
(F)
Marie Bridenne
(M)
Hélène Brihier
(H)
Laura Bril
(L)
Philippe Bulois
(P)
Pierre Burgiere
(P)
Joël Butel
(J)
Jean-Yves Canva
(JY)
Valérie Canva-Delcambre
(V)
Florence Cardot
(F)
Sandrine Carette
(S)
Pierre Carpentier
(P)
Michel Cassagnou
(M)
Jean-François Cassar
(JF)
François Castex
(F)
Pascale Catala
(P)
Stéphane Cattan
(S)
Sylviane Catteau
(S)
Bernard Caujolle
(B)
Gérard Cayron
(G)
Catherine Chandelier
(C)
Cloé Charpentier
(C)
Marthe Chavance-Thelu
(M)
Agathe Cheny
(A)
Dinu Chirita
(D)
Antoine Choteau
(A)
Jean-François Claerbout
(JF)
Pierre-Yves Clergue
(PY)
Hugues Coevoet
(H)
Gil Cohen
(G)
Marie Colin
(M)
Régis Collet
(R)
Jean-Frédéric Colombel
(JF)
Stéphanie Coopman
(S)
Lucie Cordiez
(L)
Antoine Cortot
(A)
Jean Corvisart
(J)
Frédéric Couttenier
(F)
Jean-François Crinquette
(JF)
Valérie Crombe
(V)
Abdelhakim Daoudi
(A)
Vincent Dapvril
(V)
Thierry Davion
(T)
Sébastien Decoster
(S)
Laurent Defontaine
(L)
Nicolas Degrave
(N)
Aurélien Dejaeger
(A)
Richard Delcenserie
(R)
Marine Deleplanque
(M)
Dorothée Delesalle
(D)
Olivier Delette
(O)
Thierry Delgrange
(T)
Laurence Delhoustal
(L)
Jean-Stéphane Delmotte
(JS)
Sabri Demmane
(S)
Guy Deregnaucourt
(G)
Constance Deschepper
(C)
Jean-Pierre Desechalliers
(JP)
Patrick Desmet
(P)
Pierre Desreumaux
(P)
Gérard Desseaux
(G)
Philippe Desurmont
(P)
Alain Devienne
(A)
Eve Devouge
(E)
Alex Devroux
(A)
Arnaud Dewailly
(A)
Sébastien Dharancy
(S)
Aude Di Fiore
(A)
Emmanuel Diaz
(E)
Djamal-Dine Djeddi
(DD)
Rachid Djedir
(R)
Wissam Doleh
(W)
Marie-Laure Dreher-Duwat
(ML)
Richard Dubois
(R)
Clothilde Duburque
(C)
Frédéric Ducrot
(F)
Philippe Ducrotte
(P)
André Dufilho
(A)
Christian Duhamel
(C)
Caroline Dumant-Forest
(C)
Jean-Louis Dupas
(JL)
Frédéric Dupont
(F)
Yves Duranton
(Y)
Arnaud Duriez
(A)
Nicolas Duveau
(N)
Mohammadi El Farisi
(M)
Khalil El Hachkar
(K)
Caroline Elie
(C)
Marie-Claire Elie-Legrand
(MC)
Matthieu Eoche
(M)
Essmaeel Essmaeel
(E)
Dominique Evrard
(D)
Jean-Paul Evrard
(JP)
Armelle Fatome
(A)
Karima Fellah-Sekkai
(K)
Bernard Filoche
(B)
Laurent Finet
(L)
Mathilde Flahaut
(M)
Camille Flamme
(C)
David Foissey
(D)
Peggy Fournier
(P)
Philippe Foutrein
(P)
Marie-Christine Foutrein-Comes
(MC)
Thierry Frere
(T)
Mathurin Fumery
(M)
Julie Galand
(J)
Philippe Gallais
(P)
Claudine Gamblin
(C)
Serge Ganga
(S)
Romain Gerard
(R)
Guillaume Geslin
(G)
Yves Gheyssens
(Y)
Salah Ghrib
(S)
Thierry Gilbert
(T)
Bénédicte Gillet
(B)
Denis Godart
(D)
Jean-Michel Godchaux
(JM)
Guetty Goeguebeur
(G)
Odile Goria
(O)
Frédéric Gottrand
(F)
Philippe Gower
(P)
Lucien Grados
(L)
Brigitte Grandmaison
(B)
Marion Groux
(M)
Claire Guedon
(C)
Loïc Guerbeau
(L)
Mathilde Gueroult-Dero
(M)
Jean-François Guillard
(JF)
Laurence Guillem
(L)
François Guillemot
(F)
Dominique Guimber
(D)
Baya Haddouche
(B)
Vincent Hautefeuille
(V)
Philippe Hecketsweiller
(P)
Geneviève Hecquet
(G)
Jean-Pierre Hedde
(JP)
Hassina Hellal
(H)
Pierre-Emmanuel Henneresse
(PE)
Michel Heraud
(M)
Sophie Herve
(S)
Bruno Heyman
(B)
Patrick Hochain
(P)
Philippe Houcke
(P)
Lucie Houssin-Baillly
(L)
Bruno Huguenin
(B)
Silviu Iobagiu
(S)
Shata Istanboli
(S)
Alexsandar Ivanovic
(A)
Isabelle Iwanicki-Caron
(I)
Eric Janicki
(E)
Marine Jarry
(M)
Charlotte Jean Bart
(CJ)
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(C)
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(J)
Anne Jouvenet
(A)
Naeim Kassar
(N)
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(A)
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(J)
Olivier Klein
(O)
Matthieu Kohut
(M)
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(R)
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(D)
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(JE)
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(E)
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(G)
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(A)
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(A)
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(P)
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(J)
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(M)
Denis Laude
(D)
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(C)
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(C)
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(A)
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(JP)
Pauline Le Roy
(P)
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(R)
Paul Lecieux
(P)
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(S)
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(N)
Jean Ledent
(J)
Jean Lefebvre
(J)
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(P)
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(C)
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(P)
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(B)
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(C)
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(L)
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(A)
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(E)
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(X)
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(D)
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(AB)
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(B)
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(M)
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Cécile Richez
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Juan Daniel Rodriguez
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(C)
Nathalie Talbodec
(N)
Noémie Tavernier
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(H)
Aurore Techy
(A)
Jean-Luc Thelu
(JL)
Henri Thiebault
(H)
Jean-Marie Thorel
(JM)
Christophe Thuillier
(C)
Guillaume Tielman
(G)
Manuella Tode
(M)
Jean Tonnel
(J)
Jean-Yves Touchais
(JY)
Audrey Toulemonde-Huguet
(A)
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(P)
Yvan Touze
(Y)
Léa Tran
(L)
Jean-Luc Tranvouez
(JL)
Nadia Triki
(N)
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(D)
Justine Turpin
(J)
Eric Vaillant
(E)
Claude Valmage
(C)
Dominique Vanco
(D)
Nathalie Vandaele-Bertiaux
(N)
Hélène Vandamme
(H)
Elise Vander Eeken
(EV)
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(P)
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(L)
Alain Vandewalle
(A)
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(JP)
Audrey Vanrenterghem
(A)
Charlotte Vanveuren
(C)
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(G)
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Christine Verne
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Gwenola Vernier-Massouille
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Juliette Viart
(J)
Benoît Vigneron
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Marc Vincendet
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Jacques Viot
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Y M Voiment
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(JY)
Michel Wantier
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Faustine Wartel
(F)
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(JC)
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(JL)
Nathalie Wizla
(N)
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(E)
Tajiogue Yimfor
(T)
Oana Zahara
(O)
Alberto Zalar
(A)
Sonia Zaoui
(S)
Anne Zellweger
(A)
Informations de copyright
© 2024 The Author(s).
Déclaration de conflit d'intérêts
Guillaume Savoye has served as speaker for MSD France, Ferring France, Abbvie France, and Vifor France. Mathurin Fumery has received lecture/consultant fees from Abbvie, Ferring, Tillots, MSD, Biogen, Amgen, Fresenius, Hospira, Pfizer, Celgene, Gilead, Boerhringer, Galapagos, Janssen and Takeda. Delphine Ley has received consultant fees from Sandoz and AbbVie. Thierry Paupard has received lecture/consultant fees from Abbvie, Amgen, Takeda, Janssen, Biogen, and Celltrion. Dominique Turck has received lecture fees from Sandoz. Nicolas Richard has received lecture/consultant fees from AbbVie and Takeda. The other authors state that they have no competing interests regarding this work to disclose.