Bipolar and Laplacian montages are suitable for high-gamma modulation language mapping with stereoelectroencephalography.

To determine the optimal montage and vocalization conditions for high-gamma language mapping using stereoelectroencephalography. We studied 12 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of auditory-naming related high-gamma modulations. We determined the effects of electrode montage and vocalization conditions of the response on the high-gamma (60-140 Hz) amplitudes. Compared to common average reference montage, bipolar and Laplacian montages effectively reduced the degree of auditory naming-related signal deflections in the white matter during the stimulus and response phases (mixed model estimate: -21.2 to -85.4%; On depth electrode recording, bipolar and Laplacian montages are suitable for measuring auditory naming-related high-gamma modulations in gray matter. The covert response may highlight the gray matter activity. This study helps establish the practical guidelines for high-gamma language mapping using stereoelectroencephalography.

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Copyright © 2024 Mitsuhashi, Iimura, Suzuki, Ueda, Nishioka, Nomura, Nakajima, Sugano and Kondo.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.