Endothelial cell-specific progerin expression does not cause cardiovascular alterations and premature death.
Hutchinson‐Gilford progeria syndrome
atherosclerosis
cardiovascular disease
endothelial cells
progerin
Journal
Aging cell
ISSN: 1474-9726
Titre abrégé: Aging Cell
Pays: England
ID NLM: 101130839
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
revised:
10
09
2024
received:
28
07
2024
accepted:
30
09
2024
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
aheadofprint
Résumé
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder caused by a mutation in the LMNA gene that provokes the synthesis of progerin, a mutant version of the nuclear protein lamin A that accelerates aging and precipitates death. The most clinically relevant feature of HGPS is the development of cardiac anomalies and severe vascular alterations, including massive loss of vascular smooth muscle cells, increased fibrosis, and generalized atherosclerosis. However, it is unclear if progerin expression in endothelial cells (ECs) causes the cardiovascular manifestations of HGPS. To tackle this question, we generated atherosclerosis-free mice (Lmna
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14389Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : BES-2017-079705
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : CEX2020-001041-S
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : IJC2019-040798-I
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : PID2022-137111OA-I00
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : PID2022-141211OB-I00
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : RYC2021-033805-I
Organisme : European Union NextGenerationEU/PRTR
Organisme : Instituto de Salud Carlos III
Organisme : European Regional Development Fund
Organisme : European Structural and Investment Funds
Organisme : Pro-CNIC Foundation
Organisme : Comunidad de Madrid
ID : 2017-T1/BMD-5247
Organisme : Comunidad de Madrid
ID : 2021-5A/BMD-20944
Organisme : Ministerio de Educación, Cultura y Deporte
ID : FPU16/05027
Organisme : 'la Caixa' Foundation
ID : LCF/BQ/DR19/1170012
Informations de copyright
© 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.
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