Screening for Eye Disease in Ebola Virus Disease Survivors: Program Implementation During an Active Outbreak in the North Kivu and Ituri Provinces, Democratic Republic of the Congo.
Journal
International ophthalmology clinics
ISSN: 1536-9617
Titre abrégé: Int Ophthalmol Clin
Pays: United States
ID NLM: 0374731
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
medline:
31
10
2024
pubmed:
31
10
2024
entrez:
31
10
2024
Statut:
ppublish
Résumé
First identified in the Democratic Republic of the Congo (DRC, formerly Zaire) in 1976, Ebola virus disease (EVD) outbreaks have afflicted thousands of Congolese over the past several decades. The nation's largest outbreak of EVD in 2018-2020 was complicated by security challenges as well as large case numbers across an expansive geographic region. These factors provided challenges for logistical considerations as well as clinical coverage. In conjunction with the EVD survivor care program spearheaded by the Ministry of Health in DRC, the DRC Intitut National de Recherche Biomédicale, (DRC Institut National de Recherche Biomedicale, DRC National Institute of Biomedical Research) and others, we launched a multidimensional effort to provide ophthalmic care to EVD survivors. During the engagement period, 237 EVD survivors were screened, 56% of which were women. The 237 EVD survivors constituted ∼75% of the total EVD survivors who were discharged at the time of the intervention. The mean time from EVD symptom onset to evaluation was 4.6 months ± 1.8 SD (range: 24 d to 8.5 mo). Ninety-seven (41%) of EVD survivors screened reported ocular symptoms during or after acute illness, such as itchy eyes (49%), eye pain (25%), and tears (24%). Ophthalmic findings, including retinal scarring, active uveitis, dry eye disease, cataracts, and glaucoma, were also identified. The need for continued monitoring and longitudinal care for EVD survivors is evident from the expanding body of literature pertaining to post-acute sequelae, including ophthalmic manifestations. Initiatives for such care should be conducted across and in conjunction with multidisciplinary stakeholders for contextualization and effectiveness.
Identifiants
pubmed: 39480208
doi: 10.1097/IIO.0000000000000533
pii: 00004397-202406440-00008
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
55-61Informations de copyright
Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest to disclose.
Références
WHO/International Study. Ebola haemorrhagic fever in Sudan, 1976. Report of a WHO/International Study Team. Bull World Health Organ. 1978;56:247–270.
International Commission. Ebola haemorrhagic fever in Zaire, 1976. Bull World Health Organ. 1978;56:271–293.
International Committee on Taxonomy of Viruses. Family: Filoviridae, Genus: Orthoebolavirus. Accessed August 8, 2024. https://ictv.global/report/chapter/filoviridae/filoviridae/orthoebolavirus
World Health Organization. Ebola outbreak 2022 - Équateur Province, DRC. World Health Organization. Accessed November 27, 2023. https://www.who.int/emergencies/situations/ebola-%C3%A9quateur-province-democratic-republic-of-the-congo-2022
World Health Organization. Ebola outbreak 2018-2020- North Kivu-Ituri. World Health Organization. Accessed November 27, 2023. https://www.who.int/emergencies/situations/Ebola-2019-drc-
Mulangu S, Dodd LE, Davey RT Jr., et al. A randomized, controlled trial of Ebola virus disease therapeutics. N Engl J Med. 2019;381:2293–2303.
Fischer WA 2nd, Crozier I, Bausch DG, et al. Shifting the paradigm—applying universal standards of care to Ebola virus disease. N Engl J Med. 2019;380:1389–1391.
Shantha JG, Crozier I, Hayek BR, et al. Ophthalmic manifestations and causes of vision impairment in Ebola virus disease survivors in Monrovia, Liberia. Ophthalmology. 2017;124:170–177.
PREVAIL III Study Group. A longitudinal study of Ebola sequelae in Liberia. New Engl J Med. 2019;380:924–934.5
doi: 5
Hereth-Hebert E, Bah MO, Etard JF, et al. Ocular complications in survivors of the Ebola outbreak in Guinea. Am J Ophthalmol. 2017;175:114–121.
Varkey JB, Shantha JG, Crozier I, et al. Persistence of Ebola virus in ocular fluid during convalescence. N Engl J Med. 2015;372:2423–2427.
Tiffany A, Vetter P, Mattia J, et al. Ebola virus disease complications as experienced by survivors in Sierra Leone. Clin Infect Dis. 2016;62:1360–1366.
Lötsch F, Schnyder J, Goorhuis A, et al. Neuropsychological long-term sequelae of Ebola virus disease survivors—a systematic review. Travel Med Infect Dis. 2017;18:18–23.
Mattia JG, Vandy MJ, Chang JC, et al. Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study. Lancet Infect Dis. 2016;16:331–338.
World Health Organization. Eye care for Ebola survivors. April 10, 2019. Accessed July 8, 2024. https://www.who.int/news-room/feature-stories/detail/eye-care-for-ebola-survivors
World Health Organization. Curbing Ebola resurgence risk among survivors in Democratic Republic of the Congo. 2022. Accessed July 10, 2024. https://www.afro.who.int/countries/democratic-republic-of-congo/news/curbing-ebola-resurgence-risk-among-survivors-democratic-republic-congo#:~:text=Kinshasa%20%E2%80%93%20In%202018%2C%20World%20Health,support%20them%20in%20their%20recovery.
World Health Organization. Ebola then and now: Eight lessons from West Africa that were applied in the Democratic Republic of the Congo. Updated April 2020. Accessed December 6, 2023. https://www.who.int/news-room/feature-stories/detail/ebola-then-and-now
Partners in Health. Building Strong Health Systems. Partners in Health. Accessed November 29, 2023. https://www.pih.org/our-approach
Shantha JG, Hayek BR, Crozier I, et al. Development of a screening eye clinic for Ebola virus disease survivors: Lessons learned and rapid implementation at ELWA Hospital in Monrovia, Liberia 2015. PLoS Negl Trop Dis. 2019;13:e0007209.
Shantha JG, Crozier I, Kraft CS, et al. Implementation of the Ebola virus persistence in ocular tissues and fluids (EVICT) study: lessons learned for vision health systems strengthening in Sierra Leone. PLoS One. 2021;16:e0252905.
Eghrari AO, Bishop RJ, Ross RD, et al. Characterization of Ebola virus-associated eye disease. JAMA Netw Open. 2021;4:e2032216.
Shantha JG, Canady D, Hartley C, et al. Ophthalmic sequelae and psychosocial impact in pediatric Ebola survivors. EClinicalMedicine. 2022;49:101483.
Balendra S, Williams L, Mustapha J, et al. Clinical characteristics and aetiology of uveitis in a viral haemorrhagic fever zone. Res Sq. 2023. doi:10.21203/rs.3.rs-3222203/v1.
doi: 10.21203/rs.3.rs-3222203/v1
Berry DE, Bavinger JC, Fernandes A, et al. Posterior Segment ophthalmic manifestations in Ebola survivors, Sierra Leone. Ophthalmology. 2021;128:1371–1373.
Hartley C, Bavinger JC, Kuthyar S, et al. Pathogenesis of uveitis in Ebola virus disease survivors: evolving understanding from outbreaks to animal models. Microorganisms. 2020;8:594.