Progress in Transdifferentiation of Autologous Alternative Cell Sources into Corneal Epithelial Cells.
Limbal epithelial stem cells; limbal stem cell deficiency; cell-based therapies; corneal cells differentiation
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
accepted:
20
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
31
10
2024
Statut:
aheadofprint
Résumé
Corneal limbal epithelial stem cells (LESCs) play a crucial role in corneal epithelium regeneration. Severe damage to these cells can result in limbal stem cell deficiency (LSCD), characterized by repeated corneal conjunctivalization, leading to corneal turbidity and scar formation. Restoring functional LESCs and their ecological location are essential for treating LSCD. The goal of this review is to provide researchers and clinicians with key insights into LESCs biology and to conclude the current cell-based therapies advancement in LSCD treatments. Therapeutic cell resources mainly include mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), skin keratinocyte stem cells (SKCs), and oral mucosal epithelial cells (OMECs).
Identifiants
pubmed: 39480612
doi: 10.1007/s12015-024-10808-1
pii: 10.1007/s12015-024-10808-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 82070934
Organisme : National Natural Science Foundation of China
ID : 82171025
Organisme : Fundamental Research Funds for the Central Universities
ID : HUST: 2019kfyXMBZ065
Organisme : Key Technologies Research and Development Program
ID : 2021BCA146
Organisme : Wuhan Union Hospital
ID : 2021xhlcyj03
Organisme : Hubei Provincial Population and Family Planning Commission
ID : WJ2023M035
Informations de copyright
© 2024. The Author(s).
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