Microglia cannibalism during neurodevelopment results in necroptotic cell death.


Journal

PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755

Informations de publication

Date de publication:
Oct 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 31 10 2024
Statut: epublish

Résumé

Clearance of dying neurons by microglia is critical to healthy neurodevelopment, but what else do microglia eat? A new study in PLOS Biology demonstrates that microglia not only eat neurons but each other, and that this "microglia cannibalism" causes necroptotic cell death.

Identifiants

pubmed: 39480876
doi: 10.1371/journal.pbio.3002869
pii: PBIOLOGY-D-24-02511
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

e3002869

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright: © 2024 Bennett, Bennett. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Auteurs

F Chris Bennett (FC)

Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.

Mariko L Bennett (ML)

Division of Neurology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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Classifications MeSH