Regulation of wakefulness by neurotensin neurons in the lateral hypothalamus.

Arousal Conditional ablation Fiber photometry Hypersomnia Locomotion Neurotensin Orexins

Journal

Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712

Informations de publication

Date de publication:
29 Oct 2024
Historique:
received: 22 07 2024
revised: 04 10 2024
accepted: 27 10 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 31 10 2024
Statut: aheadofprint

Résumé

The lateral hypothalamic region (LH) has been identified as a key region for arousal regulation, yet the specific cell types and underlying mechanisms are not fully understood. While neurons expressing orexins (OX) are considered the primary wake-promoting population in the LH, their loss does not reduce daily wake levels, suggesting the presence of additional wake-promoting populations. In this regard, we recently discovered that a non-OX cell group in the LH, marked by the expression of neurotensin (Nts), could powerfully drive wakefulness. Activation of these Nts

Identifiants

DOI: 10.1016/j.expneurol.2024.115035 PMID: 39481513
pubmed: 39481513
pii: S0014-4886(24)00361-3
doi: 10.1016/j.expneurol.2024.115035
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115035

Informations de copyright

Copyright © 2024. Published by Elsevier Inc.

Auteurs

Fumito Naganuma (F)

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Mudasir Khanday (M)

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States of America.

Sathyajit Sai Bandaru (SS)

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.

Whidul Hasan (W)

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States of America.

Kyosuke Hirano (K)

Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Takeo Yoshikawa (T)

Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.

Ramalingam Vetrivelan (R)

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Division of Sleep Medicine, Harvard Medical School, Boston, MA, United States of America. Electronic address: vramalin@bidmc.harvard.edu.

Classifications MeSH