Correlation of serum chloride concentrations with components of the renin-angiotensin-aldosterone system in a dog with congestive heart failure.
RAAS
diuretics
electrolytes
hypochloremia
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
31 Oct 2024
31 Oct 2024
Historique:
received:
30
07
2024
accepted:
14
10
2024
medline:
1
11
2024
pubmed:
1
11
2024
entrez:
31
10
2024
Statut:
aheadofprint
Résumé
A 7-year-old male castrated Cavalier King Charles Spaniel was hospitalized for 12 days for treatment of severe congestive heart failure secondary to myxomatous mitral valve disease. During that time, 6 serum samples from different days were analyzed for serum biochemical and renin-angiotensin-aldosterone system components. Serum chloride concentrations (ranging from 71.6 to 103.1 mmol/L) were inversely related to angiotensin I concentrations, aldosterone concentrations, a surrogate marker of renin activity, and a surrogate marker of adrenal responsiveness to angiotensin II. In light of recent studies showing that hypochloremia is associated with advanced heart failure in dogs and is associated with poor outcomes in people, the information from the dog in this report supports exploration of RAAS dysregulation as an underlying mechanism.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Kentucky RAS Analytical Laboratory
Informations de copyright
© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
Kataoka H. Chloride in heart failure syndrome: its pathophysiologic role and therapeutic implication. Cardiol Ther Adis. 2021;10:1‐19.
Bellino MC, Massari F, Albanese M, et al. Baseline and incident hypochloremia in chronic heart failure outpatients: clinical correlates and prognostic role. Eur J Intern Med. 2021;84:32‐37.
Cuthbert JJ, Bhandari S, Clark AL. Hypochloraemia in patients with heart failure: causes and consequences. Cardiol Ther. 2020;9(2):333‐347. doi:10.1007/s40119‐020‐00194‐3
Testani JM, Hanberg JS, Arroyo JP, et al. Hypochloraemia is strongly and independently associated with mortality in patients with chronic heart failure. Eur J Heart Fail. 2016;18(6):660‐668.
Adin D, Kurtz K, Atkins C, Papich MG, Vaden S. Role of electrolyte concentrations and renin‐angiotensin‐aldosterone activation in the staging of canine heart disease. J Vet Intern Med. 2020;34(1):53‐64.
Roche‐Catholy M, Van Cappellen I, Locquet L, Broeckx BJG, Paepe D, Smets P. Clinical relevance of serum electrolytes in dogs and cats with acute heart failure: a retrospective study. J Vet Intern Med. 2021;35(4):1652‐1662.
Rivera FB, Alfonso P, Golbin JM, et al. The role of serum chloride in acute and chronic heart failure: a narrative review. Cardiorenal Medicine. Vol 11. S. Karger AG; 2021:87‐98.
Huang X, Mees ED, Vos P, Hamza S, Braam B. Everything we always wanted to know about furosemide but were afraid to ask. Am J Physiol Renal Physiol. 2016;310(10):F958‐F971. doi:10.1152/ajprenal.00476.2015
Riegger ANAJG, Liebau DG, Riegger AJG. The renin‐angiotensin‐aldosterone system, antidiuretic hormone and sympathetic nerve activity in an experimental model of congestive heart failure in the dog. Clin Sci. 1982. Accessed xxxx. http://portlandpress.com/clinsci/article-pdf/62/5/465/453484/cs0620465.pdf;62:465‐469.
Potter BM, Ames MK, Hess A, Poglitsch M. Comparison between the effects of torsemide and furosemide on the renin‐angiotensin‐aldosterone system of normal dogs. J Vet Cardiol. 2019;26(June 2018):51‐62. doi:10.1016/j.jvc.2019.11.003
Sipos A, Vargas S, Peti‐Peterdi J. Direct demonstration of tubular fluid flow sensing by macula densa cells. Am J Physiol Renal Physiol. 2010;299:1087‐1093. Accessed xxxx. http://www.ajprenal.org
Zandijk AJL, van Norel MR, Julius FEC, et al. Chloride in heart failure: the neglected electrolyte. JACC: Heart Failure. Vol 9. Elsevier; 2021:904‐915.
Burrello J, Buffolo F, Domenig O, et al. Renin‐angiotensin‐aldosterone system triple—a analysis for the screening of primary aldosteronism. Hypertension. 2020;75(1):163‐172.
Pavo N, Goliasch G, Wurm R, et al. Low‐ and high‐renin heart failure phenotypes with clinical implications. Clin Chem. 2018;64(3):597‐608.
Meurs KM, Olsen LH, Reimann MJ, et al. Angiotensin‐converting enzyme activity in Cavalier King Charles Spaniels with an ACE gene polymorphism and myxomatous mitral valve disease. Pharmacogenet Genomics. 2018;28(2):37‐40.
Adin D, Atkins C, Londoño L, Del Nero B. Correction of serum chloride concentration in dogs with congestive heart failure. J Vet Intern Med. 2021;35(1):51‐57.
Cuthbert JJ, Pellicori P, Rigby A, et al. Low serum chloride in patients with chronic heart failure: clinical associations and prognostic significance. Eur J Heart Fail. 2018;20(10):1426‐1435.
Hanberg JS, Rao V, ter Maaten JM, et al. Hypochloremia and diuretic resistance in heart failure. Circ Heart Fail. 2016;9(8):1‐12.
ter Maaten JM, Damman K, Hanberg JS, et al. Hypochloremia, diuretic resistance, and outcome in patients with acute heart failure. Circ Heart Fail. 2016;9(online):1‐9.
Ehlers MR, Abrie JA, Sturrock ED. C domain‐selective inhibition of angiotensin‐converting enzyme. JRAAS. 2013;14(2):189‐192.
Rushworth CA, Guy JL, Turner AJ. Residues affecting the chloride regulation and substrate selectivity of the angiotensin‐converting enzymes (ACE and ACE2) identified by site‐directed mutagenesis. FEBS J. 2008;275(23):6033‐6042.
Uehara Y, Miura S, Yahiro E, Saku K. Non‐ACE pathway‐induced angiotensin II production. Curr Pharm des. 2013;19:3054‐3059.
Cozier GE, Lubbe L, Sturrock ED, Acharya KR. Angiotensin‐converting enzyme open for business: structural insights into the subdomain dynamics. FEBS J. 2021;288(7):2238‐2256.
Elena Ibarra‐rubio M, Angel LC, Cruz C, Pedraza‐chaverr J. Effect of chloride and diamide on serum angiotensin I‐converting enzyme activity from eight mammalian species. Biochem Physiol. 1993;106(2):495‐501.
Atkins CE, Rausch WP, Gardner SY, Defrancesco TC, Keene BW, Levine JF. The effect of amlodipine and the combination of amlodipine and enalapril on the renin‐angiotensin‐aldosterone system in the dog. J Vet Pharmacol Ther. 2007;30(5):394‐400.