Mapping bacterial extracellular vesicle research: insights, best practices and knowledge gaps.

Extracellular Vesicles / metabolism Bacteria / metabolism Humans

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
31 Oct 2024
Historique:
received: 28 04 2024
accepted: 07 10 2024
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: epublish

Résumé

Bacterial extracellular vesicles (BEVs) enable communication between bacteria and their natural habitats, including multicellular organisms such as humans. Consequently, the study of BEVs has rapidly gained attention with recent research raising the prospect of developing BEVs as biomarkers and treatments to manage (mal)functioning of natural habitats. Although diverse technologies are available, the composition of their source, their heterogeneity in biophysical and biochemical features, and their multifaceted cargo composition challenges the analysis of BEVs. To map current practices in BEV research, we analyzed 845 publications released in 2015-2021, reporting 3338 BEV-related experiments. The extracted data are accessible via the publicly available EV-TRACK knowledgebase ( https://evtrack.org/ ). We identify the need for transparent reporting, delineate knowledge gaps, outline available best practices and define areas in need of guidance to ensure advances in BEV research and accelerate BEV applications.

Identifiants

DOI: 10.1038/s41467-024-53279-1 PMID: 39482295
pubmed: 39482295
doi: 10.1038/s41467-024-53279-1
pii: 10.1038/s41467-024-53279-1
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

9410

Subventions

Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
ID : 101045156
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : S000319N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : S000319N
Organisme : Fonds Wetenschappelijk Onderzoek (Research Foundation Flanders)
ID : S000319N
Organisme : EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions)
ID : 722148

Informations de copyright

© 2024. The Author(s).

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Auteurs

Nele De Langhe (N)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
Department of Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium.

Sofie Van Dorpe (S)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
Department of Gynecology, Ghent University Hospital, Ghent, Belgium.

Niké Guilbert (N)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
ORCID: 0000-0003-4502-1246

Amélie Vander Cruyssen (A)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.

Quentin Roux (Q)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
CRCI²NA, Nantes Université, INSERM, CNRS, Nantes, France.
ORCID: 0000-0001-8720-1427

Sarah Deville (S)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
Laboratory for Molecular Diagnostics, Department of Clinical Biology, Jessa Hospital, Hasselt, Belgium.
ORCID: 0000-0002-5615-8603

Sándor Dedeyne (S)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.

Philippe Tummers (P)

Department of Gynecology, Ghent University Hospital, Ghent, Belgium.

Hannelore Denys (H)

Cancer Research Institute Ghent, Ghent, Belgium.
Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium.
ORCID: 0000-0002-8897-9430

Linos Vandekerckhove (L)

HIV Cure Research Center, Department of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent University, Ghent, Belgium.
Department of Internal Medicine and Infectious Diseases, Ghent University Hospital, Ghent, Belgium.
ORCID: 0000-0002-8600-1631

Olivier De Wever (O)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Cancer Research Institute Ghent, Ghent, Belgium.
ORCID: 0000-0002-5453-760X

An Hendrix (A)

Laboratory of Experimental Cancer Research, Department of Human Structure and Repair, Ghent University, Ghent, Belgium. an.hendrix@ugent.be.
Cancer Research Institute Ghent, Ghent, Belgium. an.hendrix@ugent.be.
ORCID: 0000-0002-1883-8309

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Mapping bacterial extracellular vesicle...
questionsmedicales.fr › Bactéries › Mapping bacterial extracellular vesicle...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mapping bacterial extracellular vesicle...